{"id":84531,"date":"2018-03-10T00:08:51","date_gmt":"2018-03-10T00:08:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-estandarizacion-de-un-banco-de-sangre-de-cordon-umbilical\/"},"modified":"2018-03-10T00:08:51","modified_gmt":"2018-03-10T00:08:51","slug":"desarrollo-y-estandarizacion-de-un-banco-de-sangre-de-cordon-umbilical","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-y-estandarizacion-de-un-banco-de-sangre-de-cordon-umbilical\/","title":{"rendered":"Desarrollo y estandarizacion de un banco de sangre de cordon umbilical"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Bornstein Sanchez <\/strong><\/h2>\n<p>El objetivo principal de este estudio ha sido la evaluaci\u00f3n y estandarizaci\u00f3n de protocolos para la creaci\u00f3n de un banco de sangre de cord\u00f3n umbilical(scu), habiendo sido desglosado en dos objetivos parciales: la caracterizaci\u00f3n de la scu mediante estudio experimental de las propiedades hematopoy\u00e9ticas e inmunol\u00f3gicas de la misma, y la puesta a punto del procesamiento de scu para su validaci\u00f3n como unidades trasplantables. Se ha realizado un an\u00e1lisis fenot\u00edpico y de clonogenicidad de c\u00e9lulas hematopoy\u00e9ticas, as\u00ed como un estudio fenot\u00edpico y funcional de poblaciones linfocitarias de scu, compar\u00e1ndose con muestras control de m\u00e9dula \u00f3sea(mo) y sangre perif\u00e9rica de adultos(spa). respecto al segundo objetivo del trabajo, se ha hecho un estudio comparativo de diferentes protocolos de obtenci\u00f3n, fracionamiento y congelaci\u00f3n con el fin de preservar la m\u00e1xima celularidad y viabilidad en las unidades procesadas. Asimismo, para su validaci\u00f3n definitiva, se han definido criterios normalizados que incluyen la tipificaci\u00f3n del complejo hla con t\u00e9cnicas de alta resoluci\u00f3n y la detecci\u00f3n de posibles enfermedades transmisibles que garantice la seguridad en los eventuales receptores de trasplante. las conclusiones globales de este estudio son:1) la proporci\u00f3n de c\u00e9lulas progenitoras hematopoy\u00e9ticas es superior en scu que en mo y spa movilizada, lo que sugiere un mayor potencial de repoblaci\u00f3n hematopoy\u00e9tica;2) los linfocitos de scu muestran una relativa inmadurez fenot\u00edpica y funcional que permite predecir un menor potencial de enfermedad injerto contra huesped asociado a la scu;3) la combinaci\u00f3n de venopunci\u00f3n y perfusi\u00f3n de la placenta enriquece significativamente la celularidad de las unidades; 4) la scu conservada a 4\u00c2\u00ba c m\u00e1s de 12 horas sufre una reducci\u00f3n importante en la clonogenicidad y viabilidad celular;5) se ha optimizado la estandarizaci\u00f3n de m\u00e9todos de procesamiento basada en el empleo de hidroxietil almid\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y estandarizacion de un banco de sangre de cordon umbilical<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y estandarizacion de un banco de sangre de cordon umbilical <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Bornstein Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Florinda Gilsanz Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo D\u00edaz-rubio Garc\u00eda <\/li>\n<li>Miguel \u00e1ngel Sanz alonso (vocal)<\/li>\n<li>carmela Cales bourdet (vocal)<\/li>\n<li>\u00e1lvaro Urbano ispiz\u00faa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Bornstein Sanchez El objetivo principal de este estudio ha sido la evaluaci\u00f3n y estandarizaci\u00f3n de protocolos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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