{"id":84540,"date":"2018-03-10T00:08:51","date_gmt":"2018-03-10T00:08:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-del-modelo-experimental-de-la-enfermedad-de-parkinson-en-primates-mediante-infusion-intracerebral-de-factores-de-crecimiento\/"},"modified":"2018-03-10T00:08:51","modified_gmt":"2018-03-10T00:08:51","slug":"tratamiento-del-modelo-experimental-de-la-enfermedad-de-parkinson-en-primates-mediante-infusion-intracerebral-de-factores-de-crecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-del-modelo-experimental-de-la-enfermedad-de-parkinson-en-primates-mediante-infusion-intracerebral-de-factores-de-crecimiento\/","title":{"rendered":"Tratamiento del modelo experimental de la enfermedad de parkinson en primates mediante infusion intracerebral de factores de crecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julio Albisua Sanchez <\/strong><\/h2>\n<p>Introduccion:el tratamiento de la enfermedad de parkinson, aunque muy mejorado tras la introducci\u00f3n de la l-dopa, continua siendo incompleto y con importantes efectos secundarios. La infusi\u00f3n de factores de crecimiento ha presentado resultados prometedores en roedores para el tratamiento de la enferemedad de parkinson, pero existe poca evidencia de su efecto en animales filogen\u00e9ticamente m\u00e1s pr\u00f3ximos al hombre.  material y metodos:se utilizaron 11 monos cynomolgus, lesionados mediante infusi\u00f3n de mptp en car\u00f3tida izquierda. Tres fueron tratados con infusi\u00f3n intracerebral de factor de crecimiento epid\u00e9rmico (egf), dos con factor de crecimiento de los fibroblastos (ege) y 6 de grupos control. Se realiz\u00f3 control cl\u00ednico , de lcr, pet e histolog\u00eda.  resultados: con respecto al grupo control, los monos tratados con egf presentaron una mejoria transitoria que no dur\u00f3 hasta el final del experimento. Los monos tratados con fgf presentaron una clara mejor\u00eda cl\u00ednica que se confirmo en el estudio pet y la tinci\u00f3n neuronal con tirosina hidroxilasa.  discusion: es posible que el efecto beneficioso en el grupo egf fuera insuficiente para evitar el deterioro progresivo de los animales, y por eso no pudiera evidenciarse en el estudio final. Los monos fgf mejoraron claramente en todos los aspectos.  conclusiones: el modelo de lesi\u00f3n mediante inyecci\u00f3n unilateral de mptp en car\u00f3tida interna fue eficaz y mejor\u00f3 el manejo de los monos y los estudios subsiguientes . El tratamiento con facatores de crecimiento en infusi\u00f3n intracerebral, principalmente fgf y transitoriamente egf, fue benedicioso para el modelo experimental de enfermedad de parkinson en primates.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento del modelo experimental de la enfermedad de parkinson en primates mediante infusion intracerebral de factores de crecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento del modelo experimental de la enfermedad de parkinson en primates mediante infusion intracerebral de factores de crecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julio Albisua Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Justo Garc\u00eda  De Y\u00e9benes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Munuera Martinez <\/li>\n<li>M\u00aa rosario Luquin piudo (vocal)<\/li>\n<li>poza Maximo poza (vocal)<\/li>\n<li>lobato Ramiro diez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julio Albisua Sanchez Introduccion:el tratamiento de la enfermedad de parkinson, aunque muy mejorado tras la introducci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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