{"id":84543,"date":"2018-03-10T00:08:51","date_gmt":"2018-03-10T00:08:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-sobre-el-descifrado-del-codigo-estructural-de-las-protea%c2%adnas-propensiones-estada%c2%adsticas-e-informacion-multirresidual\/"},"modified":"2018-03-10T00:08:51","modified_gmt":"2018-03-10T00:08:51","slug":"estudios-sobre-el-descifrado-del-codigo-estructural-de-las-protea%c2%adnas-propensiones-estada%c2%adsticas-e-informacion-multirresidual","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-sobre-el-descifrado-del-codigo-estructural-de-las-protea%c2%adnas-propensiones-estada%c2%adsticas-e-informacion-multirresidual\/","title":{"rendered":"Estudios sobre el descifrado  del c\u00f3digo estructural de las prote\u00ednas: propensiones estad\u00edsticas e informaci\u00f3n multirresidual"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Negrete Rodriguez Jos\u00e9 Antonio <\/strong><\/h2>\n<p>A la hora de realizar el dise\u00f1o de una prote\u00edna, es muy importante la correcta elecci\u00f3n de los amino\u00e1cidos que van a formar parte de la secuencia.En primer lugar hay que elegir aquellos amino\u00e1cidos que tengan la mayor tendencia a estabilizar la estructura secundaria que queremos formar. Para ello, se emplean los par\u00e1metros de propensi\u00f3n de los amino\u00e1cidos, que son una medida de la tendencia que tienen los amino\u00e1cidos a estabilizar o desestabilizar una estructura secundaria concreta. Por otro lado, hay que distribuir dichos amono\u00e1cidos en la secuencia (en funci\u00f3n del car\u00e1cter hidrof\u00f3bico o hidrof\u00edlico de la cadena lateral), de manera que al plegarse la cadena polipept\u00eddica, las interacciones de las estructuras secundarias entre s\u00ed y con el solvente sean \u00f3ptimas. Para cada esructura ssecundaria, existen unas distribuciones \u00f3ptimas o patrones de distribuci\u00f3n caracter\u00edsticos.  el objetivo de esta tesis es profundizar en el estudio de los par\u00e1metros de propensi\u00f3n y de los patrones de distribuci\u00f3n de los amino\u00e1cidos tanto para h\u00e9lice alfa como para cadena beta. Para ello, se ha realizado un exhaustivo an\u00e1lisis estad\u00edstico de patrones de distribuci\u00f3n y de par\u00e1metros de propensi\u00f3n en una muestra de 3863 h\u00e9lices alfa (obtenidas a partir de 546 prote\u00ednas) y en una muestra de 6362 cadenas beta (obtenidas a partir de 834 prote\u00ednas). dicho an\u00e1lisis nos ha permitido obtener nuevas caracter\u00edsticas de la h\u00e9lice alfa y de la l\u00e1mina beta en prote\u00ednas globulares y establecer as\u00ed reglas \u00fatiles para el modelaje proteico.  los resultados m\u00e1s relevantes obtenidos en esta tesis respecto al an\u00e1lisis de par\u00e1metros de propensi\u00f3n han sido:  a,-demostrar la independencia de las propensiones de h\u00e9lice alfa respecto la clase estructural.  b,- demostrar la dependencia de las propensiones de cadena beta del tipo de l\u00e1mina paralela o antiparalela.  respecto al an\u00e1lisis de patrones de distribuci\u00f3n de amino\u00e1cidos se han<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios sobre el descifrado  del c\u00f3digo estructural de las prote\u00ednas: propensiones estad\u00edsticas e informaci\u00f3n multirresidual<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios sobre el descifrado  del c\u00f3digo estructural de las prote\u00ednas: propensiones estad\u00edsticas e informaci\u00f3n multirresidual <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Negrete Rodriguez Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaume Palau Albet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Subirana torrent <\/li>\n<li>ignacio Fita rodriguez (vocal)<\/li>\n<li>enrique Querol murillo (vocal)<\/li>\n<li>antoni Romeu figuerola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Negrete Rodriguez Jos\u00e9 Antonio A la hora de realizar el dise\u00f1o de una prote\u00edna, es muy importante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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