{"id":84565,"date":"2018-03-10T00:08:51","date_gmt":"2018-03-10T00:08:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-de-los-mediadores-de-la-inflamacion-en-un-modelo-experimental-de-isquemia-reperfusion-intestinal-en-ratas-diabeticas-tipo-ii\/"},"modified":"2018-03-10T00:08:51","modified_gmt":"2018-03-10T00:08:51","slug":"modificacion-de-los-mediadores-de-la-inflamacion-en-un-modelo-experimental-de-isquemia-reperfusion-intestinal-en-ratas-diabeticas-tipo-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificacion-de-los-mediadores-de-la-inflamacion-en-un-modelo-experimental-de-isquemia-reperfusion-intestinal-en-ratas-diabeticas-tipo-ii\/","title":{"rendered":"Modificaci\u00f3n de los mediadores de la inflamaci\u00f3n en un modelo experimental de isquemia-reperfusi\u00f3n intestinal en ratas diab\u00e9ticas tipo ii."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Perez Juan  Carlos <\/strong><\/h2>\n<p>Es probable que haya una mayor predisposici\u00f3n de los pacientes diab\u00e9ticos al da\u00f1o tisular secundario a procesos inflamatorios. Esto puede ser debido a:  1) aumento del estr\u00e9s oxidativo.  2) una disminuci\u00f3n en la producci\u00f3n basal de no.  tanto el aumento del estr\u00e9s oxidativo, como la disminuci\u00f3n basal del no conducen a incrementar el da\u00f1o celular producido por la isquemia, y aumentar\u00edan la producci\u00f3n de otros mediadores inflamatorios, cerrando un c\u00edrculo vicioso.  para llegar a estos razonamientos hemos utilizado un modelo experimental de ratas diab\u00e9ticas, mediante la administraci\u00f3n de estreptozotocina por v\u00eda intra-abdominal. A los dos meses del nacimiento, las ratas n fueron sometidas a una sobrecarga oral de glucosa para determinar que ratas se comportaban como diab\u00e9ticas tipo ii.  la inyecci\u00f3n de estreptozotocina se realiz\u00f3 en el d\u00eda de su nacimiento. despu\u00e9s de la sobrecarga oral de glucosa, se hicieron dos grupos:  en el primer grupo las ratas fueron sometidas a una laparotom\u00eda,mediante clampaje de la arteria mesent\u00e9rica se practic\u00f3 una isquemia intestinal de una hora, y cierre. Al cabo de una hora segunda laparotom\u00eda, cinco minutos de reperfusi\u00f3n, y estracci\u00f3n de muestras de p\u00e1ncreas, intestino delgado, sangre de porta, cava suprahep\u00e1tica e infrahep\u00e1tica.  el segundo grupo fue sometido a una operaci\u00f3n simulada.  todas las muestras se centrifugaron y se congelaron a -80 grados, hasta el momento de su determinaci\u00f3n.  hemos determinado niveles plasm\u00e1ticos de tnf alpha,il-1,il-6,il-10,tnfr1,tnfr2, lpo, co,no e icam-1. Tambi\u00e9n hemos determinado niveles en p\u00e1ncreas e intestino de : tnf alpha, il-1, il-6, il-10 y mcp-1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaci\u00f3n de los mediadores de la inflamaci\u00f3n en un modelo experimental de isquemia-reperfusi\u00f3n intestinal en ratas diab\u00e9ticas tipo ii.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaci\u00f3n de los mediadores de la inflamaci\u00f3n en un modelo experimental de isquemia-reperfusi\u00f3n intestinal en ratas diab\u00e9ticas tipo ii. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Perez Juan  Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias perez <\/li>\n<li>daniel Casanova rituerto (vocal)<\/li>\n<li>joaquin Alvarez rodriguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Perez Juan Carlos Es probable que haya una mayor predisposici\u00f3n de los pacientes diab\u00e9ticos al da\u00f1o 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