{"id":84569,"date":"2018-03-10T00:08:55","date_gmt":"2018-03-10T00:08:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacio-fenota%c2%adpica-i-funcional-de-les-diferents-subpoblacions-de-cel-lules-t-autoreactives-a-les-malalties-autoimmunitaries-de-la-tiroide\/"},"modified":"2018-03-10T00:08:55","modified_gmt":"2018-03-10T00:08:55","slug":"caracterizacio-fenota%c2%adpica-i-funcional-de-les-diferents-subpoblacions-de-cel-lules-t-autoreactives-a-les-malalties-autoimmunitaries-de-la-tiroide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacio-fenota%c2%adpica-i-funcional-de-les-diferents-subpoblacions-de-cel-lules-t-autoreactives-a-les-malalties-autoimmunitaries-de-la-tiroide\/","title":{"rendered":"Caracterizaci\u00f3 fenot\u00edpica i funcional de les diferents subpoblacions de c\u00e9l-lules t autoreactives a les malalties autoimmunitaries de la tiroide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carme Roura Mir <\/strong><\/h2>\n<p>El objetivo de este trabajo es profundizar en el estudio de la respuesta celular en las patolog\u00edas autoinmunes del tiroides y en concreto, en la enfermedad de graves-basedow(gd) y la tiroiditis de hashimoto(ht), caracterizando fenot\u00edpica y funcionalmente las celulas t autoreactivas y reguladoras implicadas. el an\u00e1lisis de las c\u00e9lulas t a b convencionales(t a b cd4+ o t a b cd8+) ha demostrado que a nivel poblacional los linfocitos t infiltrantes (itls) de los tiroides afectados por gd utilizan un repertorio muy amplio de familias tcrvb, reflejando las heterogeneidad de los ep\u00edtopos autoantig\u00e9nicos diana de la respuesta en la etapa cr\u00f3nica de la enfermedad. El repertorio tcrvb de las lineas clonales de c\u00e9lulas t autorreactivas aisladas a partir de los itls con especificidad antig\u00e9nica conocida mantiene la misma heterogeneidad que en los itls, con predominancia de alguna familia vb en cada muestra, sin relaci\u00f3n aparente con la especificidad antig\u00e9nica. Estas lineas muestran baja afinidad por el ant\u00edgeno. A nivel de cdr3, sin embargo, hay cierta restricci\u00f3n tcrvb. Tambi\u00e9n es heterog\u00e9neo el patr\u00f3n de sintesis de citocinas. en gd y ht se sintetiza tanto il4 como ifny,siendo las c\u00e9lulas t actividas, funcionalmente dominantes en gd, celulas cd4+ y productoras de il4 y en ht,cd8+ y ifny+. Tambien forman parte de los infiltrados celulas ty   que constituyen un 4-33% del total en gd, un 1-8% en ht y s\u00f3lo un 1% en la muestra de mng. El repertorio de tcr est\u00e1 m\u00e1s restringido, con dos familias v    dominantes en los itls de gd y ht, v  3 y  v  5,pero s\u00f3lo v  5 representa una expansi\u00f3n intratisular en relaci\u00f3n a los pbls de individuos control. el clon tcry   aislado a partir de los infiltrados, 158re.2, tiene tcr poco usual formado por las cadenas variables v  5 i vy8. Adem\u00e1s tiene especificidad por c\u00e9lulas epiteliales de origen endocrino y, especificamente, por c\u00e9lulas epiteliales tiroideas (cft), independientemente del tipaj<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3 fenot\u00edpica i funcional de les diferents subpoblacions de c\u00e9l-lules t autoreactives a les malalties autoimmunitaries de la tiroide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3 fenot\u00edpica i funcional de les diferents subpoblacions de c\u00e9l-lules t autoreactives a les malalties autoimmunitaries de la tiroide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carme Roura Mir <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dolores Jaraquemada P\u00e9rez De Guzm\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pujol borrell <\/li>\n<li>jordi Yag\u00ed\u00bce ribes (vocal)<\/li>\n<li>Miguel L\u00f3pez botet (vocal)<\/li>\n<li>ram\u00f3n Vilella puig (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carme Roura Mir El objetivo de este trabajo es profundizar en el estudio de la respuesta celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4229,849,160,115,35,9399,1737,17],"tags":[178586,6522,68567,15393,34038,13791],"class_list":["post-84569","post","type-post","status-publish","format-standard","hentry","category-anticuerpos-de-tejidos","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-cultivo-celular","category-inmunologia","category-quimica","tag-carme-roura-mir","tag-dolores-jaraquemada-perez-de-guzman","tag-jordi-yagie-ribes","tag-miguel-lopez-botet","tag-ramon-vilella-puig","tag-ricardo-pujol-borrell"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84569"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84569\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}