{"id":84585,"date":"2018-03-10T00:08:55","date_gmt":"2018-03-10T00:08:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-proceso-de-sintesis-de-proteinas-en-aspergillus-fumigatus-como-diana-terapeutica-de-nuevos-agentes-antifungicos\/"},"modified":"2018-03-10T00:08:55","modified_gmt":"2018-03-10T00:08:55","slug":"el-proceso-de-sintesis-de-proteinas-en-aspergillus-fumigatus-como-diana-terapeutica-de-nuevos-agentes-antifungicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/el-proceso-de-sintesis-de-proteinas-en-aspergillus-fumigatus-como-diana-terapeutica-de-nuevos-agentes-antifungicos\/","title":{"rendered":"El proceso de sintesis de proteinas en aspergillus fumigatus como diana terapeutica de nuevos agentes antifungicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Teresa Zamarro Molina <\/strong><\/h2>\n<p>La aspergilosis presenta dificulatades para conseguir un r\u00e1pido diagn\u00f3stico y frecuente fracaso terap\u00e9utico. Para resolver los problemas de profilaxix y tratamiento deben encontrarse nuevas mol\u00e9culas con capacidad antif\u00fangica. aspergillus fumigatus, especie m\u00e1s pat\u00f3gena del g\u00e9nero aspergillus princial responsable de la aspergilosis en sus formas m\u00e1s severas, es el objeto de estudio del presente trabajo.  el objetivo es encontrar y caracterizar aspectos bioqu\u00edmicos, dentro de su fisiolog\u00eda, que sean susceptibles de ser inhibidos eficaz y selectivamente, afectando a su viabilidad celular. Todo ello, deber\u00e1 traducirse en el desarrollo de ensayos bioqu\u00edmicos que permitan la b\u00fasqueda de compuestos inhibidores a traves de programas de screening. De todas las posibles o potenciales dianas antif\u00fangicas, se ha elegido el proceso de s\u00edntesis de prote\u00ednas frente a otras dianas m\u00e1s explotadas, como las pared celular o la membrana plasm\u00e1tica.  se ha conseguido la optimizaci\u00f3n y estandarizqaci\u00f3n de las condiciones de cultivo de a. Fumigatus, tanto en matraz como en fermentador, para obtener sistemas libres de c\u00e9lulas cona ctividad en s\u00edntesis de prote\u00ednas. Coneste material biol\u00f3gico se ha desarrollado un ensayo de elongaci\u00f3n a aprtir de un mensajero sint\u00e9tico, adpatado a un formato que permite el desarrollo de programas de hts. El procesode screeing realizado ha rendido mel\u00f3culas que finalmente se han mostrado no selectivas o t\u00f3xicas, por lo que no han podido progresar a estudios posteriores.  analizado el efecto de los derivados de sordarina, se ha puesto en evidencia que producen un efecto de inhibici\u00f3n reversible en el proceso de s\u00edntesis de prote\u00ednas, responsable del efecto fungist\u00e1tico del crecimiento de a. fumigatus, demostr\u00e1ndose que la diana molecular dentro del ciclo de elongaci\u00f3nd e estos agentes antif\u00fangicos en a. Fumigatus es el factor de elongaci\u00f3n ef-2. De todos los derivados analizados, el dierivad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El proceso de sintesis de proteinas en aspergillus fumigatus como diana terapeutica de nuevos agentes antifungicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El proceso de sintesis de proteinas en aspergillus fumigatus como diana terapeutica de nuevos agentes antifungicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Teresa Zamarro Molina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Martin Plaza Jos\u00e9 Julio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Gavilanes franco <\/li>\n<li>Juan  pedro Garc\u00eda ballesta (vocal)<\/li>\n<li>domingo Gargallo viola (vocal)<\/li>\n<li> Rodriguez tudela Juan  Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Teresa Zamarro Molina La aspergilosis presenta dificulatades para conseguir un r\u00e1pido diagn\u00f3stico y frecuente fracaso terap\u00e9utico. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[102115,25610,14711,178600,178601,65104],"class_list":["post-84585","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-domingo-gargallo-viola","tag-jose-gavilanes-franco","tag-juan-pedro-garcia-ballesta","tag-maria-teresa-zamarro-molina","tag-martin-plaza-jose-julio","tag-rodriguez-tudela-juan-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84585"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84585\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}