{"id":84594,"date":"2018-03-10T00:08:55","date_gmt":"2018-03-10T00:08:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sindrome-de-la-respuesta-inflamatoria-sistemica-y-fallo-multiorganico-en-un-modelo-experimental-de-translocacion-bacteriana-respuesta-renal-y-su-regulacion-con-tacrolimus\/"},"modified":"2018-03-10T00:08:55","modified_gmt":"2018-03-10T00:08:55","slug":"sindrome-de-la-respuesta-inflamatoria-sistemica-y-fallo-multiorganico-en-un-modelo-experimental-de-translocacion-bacteriana-respuesta-renal-y-su-regulacion-con-tacrolimus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sindrome-de-la-respuesta-inflamatoria-sistemica-y-fallo-multiorganico-en-un-modelo-experimental-de-translocacion-bacteriana-respuesta-renal-y-su-regulacion-con-tacrolimus\/","title":{"rendered":"Sindrome de la respuesta inflamatoria sist\u00e9mica y fallo multiorg\u00e1nico en un modelo experimental de translocaci\u00f3n bacteriana. respuesta renal y su regulaci\u00f3n con tacrolimus."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Fernanda Lorenzo Gomez <\/strong><\/h2>\n<p>En el intento de valorar nuevos mecanismos de acci\u00f3n del inmunosupresor tacrolimus,hemos estudiado en esta tesis doctoral su actuaci\u00f3n sobre la respuesta inflamatoria en un modelo experimental de fallo multiorg\u00e1nico originado por un proceso de translocaci\u00f3n bacteriana.  utilizamkos ratas wistar a las cuales adminsitramos seiscientos mil\u00edgramos de zomosan para provocar una respeusta inflamatoria sist\u00e9mica de la que se derivanran tanto la translocaci\u00f3n bacteriana como el fallo multiorg\u00e1ncio. estudiamos la supervivencia, estudio microbiol\u00f3gico de la translocaci\u00f3n bacteriana cuali-cuantitavio, pruebas de funci\u00f3n nenal, infiltraci\u00f3nneutrof\u00edlica, estado eoxidante, citocinas, expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n celualr, activaci\u00f3n de factores transcripcionales.  los resultados demuestras el control que el tacrolimus ejerce sobre la respuesta inflamatoria disminuyendo la activaci\u00f3n del factor trasncripcional kb y la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n celular como icam-1 pecam-1, vcam-1 y p-selectina. Consecuentemente obsevamos una disminuci\u00f3n de la infiltraci\u00f3n neutrof\u00edlica de la producci\u00f3n de radicales libres del \u00f3xigeno (ani\u00f3n super\u00f3xido)  y la liberaci\u00f3n de citocinas (tnf, il-1, inf) comprobando un incremento significativo en la producci\u00f3n de la il-10. Todo ello llevan a comprobar una disminucci\u00f3n del amorbi-mortalidad en el modelo experimental, haciendo del tacrolimus un inmosupresor con un mecanismo paralelo de acci\u00f3n anti-inflamatorio de primer orden.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sindrome de la respuesta inflamatoria sist\u00e9mica y fallo multiorg\u00e1nico en un modelo experimental de translocaci\u00f3n bacteriana. respuesta renal y su regulaci\u00f3n con tacrolimus.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sindrome de la respuesta inflamatoria sist\u00e9mica y fallo multiorg\u00e1nico en un modelo experimental de translocaci\u00f3n bacteriana. respuesta renal y su regulaci\u00f3n con tacrolimus. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Fernanda Lorenzo Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Criado Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Casti\u00f1eiras fern\u00e1ndez <\/li>\n<li> Mercha cifuentes Miguel angel (vocal)<\/li>\n<li>Jaime Mendez martin (vocal)<\/li>\n<li>Javier Arias diez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Fernanda Lorenzo Gomez En el intento de valorar nuevos mecanismos de acci\u00f3n del inmunosupresor tacrolimus,hemos estudiado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,1533,9386],"tags":[68465,10122,62384,20642,178612,178613],"class_list":["post-84594","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-cirugia-urologica","category-salamanca","tag-garcia-criado-francisco-javier","tag-jaime-mendez-martin","tag-javier-arias-diez","tag-jesus-castineiras-fernandez","tag-m-fernanda-lorenzo-gomez","tag-mercha-cifuentes-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84594"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84594\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}