{"id":84618,"date":"2018-03-10T00:08:55","date_gmt":"2018-03-10T00:08:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-preclinico-de-la-eficacia-antitumoral-y-toxicidad-de-la-transferencia-genica-de-la-interleuquina-12-mediada-por-adenovirus-en-el-tratamiento-del-cancer-de-colon\/"},"modified":"2018-03-10T00:08:55","modified_gmt":"2018-03-10T00:08:55","slug":"estudio-preclinico-de-la-eficacia-antitumoral-y-toxicidad-de-la-transferencia-genica-de-la-interleuquina-12-mediada-por-adenovirus-en-el-tratamiento-del-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-preclinico-de-la-eficacia-antitumoral-y-toxicidad-de-la-transferencia-genica-de-la-interleuquina-12-mediada-por-adenovirus-en-el-tratamiento-del-cancer-de-colon\/","title":{"rendered":"Estudio preclinico de la eficacia antitumoral y toxicidad de la transferencia genica de la interleuquina 12 mediada por adenovirus en el tratamiento del cancer de colon."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guillermo Mazzolini Rizzo <\/strong><\/h2>\n<p>Una de las estrategias que se utilizan en la inmunoterapia del cancer consiste en la transferencia de genes inmunomodulares que sean capaces de inducir un potente respuesta inmunitaria frente al tumor. En esta memoria, hemos observado que la aplicaci\u00f3n intratumoral directa de un vector adenoviral que codifica para los genes de la il-12 estimula en el huesped del desarrollo de respuesta inmunitaria especifica que permite eliminar los tumores de cc. La inmunoterapia activa con il-12 favorece el desarrollo de linfocitos antitumorales especificos de tumor que, aplicados en combinacion con el vector adcmvmil-12, act\u00faan de manera sin\u00e9rgica en la eliminaci\u00f3n del cc metastasico en higado. Esta sinergia parece sustentarse por un lado, en la inducci\u00f3n de la expresi\u00f3nd de vcam-1 en los tumores, hecho que favorec\u00eda la migraci\u00f3n de los ctls especificos antitumorales hacia el tejido tumoral, y por otro lado, la propia il-12 es capaz de inhibir la formaci\u00f3n de neovasos en el tumor. Tanto esta \u00faltima situaci\u00f3n como la llegada eficiente de los linfocitos al tumor permitir\u00edan eliminar con eficacia los tumores experimentales de cc metast\u00e1sico. Nuestro sistema de transferencia g\u00e9nica se basa en la aplicaci\u00f3n intralesional de adcmvmil-12, para evitar los efectos t\u00f3xicos que conlleva su adminsitracion sistematica. Empleado en dosis elevadas, el ventor adcmvmil-12, es  capaz de producir importantes cantidades de ifn-y,el cual parece mediar la mayoria de los efectos t\u00f3xicos que induce la il-12. Hemos observado que en diferentes cepas de ratones, la respuesta t\u00f3xica y la producci\u00f3n de ifn-y son variables. De manera similar, los linfocitos provenientes de sangre periferica de los pacientes sanos estudiados, tambien producen de forma variable ifn-y en respuesta a la il-12.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio preclinico de la eficacia antitumoral y toxicidad de la transferencia genica de la interleuquina 12 mediada por adenovirus en el tratamiento del cancer de colon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio preclinico de la eficacia antitumoral y toxicidad de la transferencia genica de la interleuquina 12 mediada por adenovirus en el tratamiento del cancer de colon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guillermo Mazzolini Rizzo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Javier Melero Bermejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pilar Civeira murillo <\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<li>Fernando Vidal vanaclocha (vocal)<\/li>\n<li> Novo villaverde Francisco Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guillermo Mazzolini Rizzo Una de las estrategias que se utilizan en la inmunoterapia del cancer consiste en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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