{"id":84645,"date":"2018-03-10T00:08:59","date_gmt":"2018-03-10T00:08:59","guid":{"rendered":""},"modified":"2018-03-10T00:08:59","modified_gmt":"2018-03-10T00:08:59","slug":"progenitores-linfohematopoyeticos-del-embrion-de-raton-post-gastrulacion-estudio-de-sus-caracteristicas-celulares-y-establecimiento-de-lineas-b-de-larga-evolucion-in-vitro-no-transformadas-y-funci","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/progenitores-linfohematopoyeticos-del-embrion-de-raton-post-gastrulacion-estudio-de-sus-caracteristicas-celulares-y-establecimiento-de-lineas-b-de-larga-evolucion-in-vitro-no-transformadas-y-funci\/","title":{"rendered":"Progenitores linfohematopoyeticos del embrion de raton post-gastrulacion. estudio de sus caracteristicas celulares y establecimiento de lineas b de larga evolucion \u00abin vitro\u00bb, no transformadas y funcionales, capaces de reconstituir individuos adultos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Marin Jos\u00e9 Alberto <\/strong><\/h2>\n<p>La finalidad de este trabajo es el estudio de los procesos y v\u00edas de diferenciaci\u00f3n de los progenitores embrionarios y el an\u00e1lisis de sus diferencias con los que se producen en estadios ontog\u00e9nicos m\u00e1s avanzados. L\u00edneas celulares de diferentes \u00e1reas linfohematopoy\u00e9ticas del embri\u00f3n post-gastrulaci\u00f3n (esplachnopleura paraa\u00f3rtica, h\u00edgado, saco vitelino y sangre) y del adulto (h\u00edgado fetal tard\u00edo y m\u00e9dula \u00f3sea), se establecieron en cultivo en condiciones estroma\/il-7 dependientes. Los progenitores embrionarios son m\u00e1s sensibles a las se\u00f1ales de proliferaci\u00f3n y supervivencia de la il-7, ya que la frecuencia de obtenci\u00f3n de l\u00edneas a partir de precursores embionarios a concentraciones limitadas de il-7, es mayor que para progenitores procedentes del adulto. a pesar de crecer en condiciones id\u00e9nticas, diversos aspectos de su programa de desarrollo \u00abin vitro\u00bb se mantienen de forma distinta entre las l\u00edneas embrionarias y adultas, como la expresi\u00f3n de b220, ie, tdt y pax5\/bsap. las l\u00edneas embrionarias, que son policlonales, incluyen distintas poblaciones en diferentes estadios de desarrollo, desde los pregenitores pro-b m\u00e1s inmaduros, pasando por c\u00e9lulas pre-b hasta, incluso, el estadio de linfocito b inmaduro. Los linfocitos b, generados en estas l\u00edneas celulares responden eficientemente \u00abin vitro\u00bb a est\u00edmulos convencionales tanto t-independientes como t-dependientes. Las l\u00edneas b embrionarias presentan un notable potencial de expanci\u00f3n y reconstruci\u00f3n de ratones inmunodeficientes adultos tras su transferencia y son capaces de generar respuestas inmunes humorales espec\u00edficas \u00abin vivo\u00bb tras una inmunizaci\u00f3n convencional. Estas l\u00edneas celulares obtenidas del embri\u00f3n de rat\u00f3n son f\u00e1cilmente transfectables \u00abin vitro\u00bb. Por todo ello, proponemos que la generaci\u00f3n y difusi\u00f3n de l\u00edneas linfoides b de origen ontog\u00e9nico temprano (rat\u00f3n postgastrulaci\u00f3n) puede representar una importante herramienta para abordar la b<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Progenitores linfohematopoyeticos del embrion de raton post-gastrulacion. estudio de sus caracteristicas celulares y establecimiento de lineas b de larga evolucion \u00abin vitro\u00bb, no transformadas y funcionales, capaces de reconstituir individuos adultos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Progenitores linfohematopoyeticos del embrion de raton post-gastrulacion. estudio de sus caracteristicas celulares y establecimiento de lineas b de larga evolucion \u00abin vitro\u00bb, no transformadas y funcionales, capaces de reconstituir individuos adultos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Marin Jos\u00e9 Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>vega M. Luisa Gaspar Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fernandez rodriguez Manuel nicolas <\/li>\n<li>africa Gonzalez fernandez (vocal)<\/li>\n<li>Manuel Fresno (vocal)<\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Marin Jos\u00e9 Alberto La finalidad de este trabajo es el estudio de los procesos y v\u00edas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,32218,1737],"tags":[42968,63249,40871,15111,178701,86840],"class_list":["post-84645","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-formacion-de-anticuerpos","category-inmunologia","tag-africa-gonzalez-fernandez","tag-fernandez-rodriguez-manuel-nicolas","tag-isidro-javier-sanchez-garcia","tag-manuel-fresno","tag-Martinez-marin-jose-alberto","tag-vega-m-luisa-gaspar-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84645"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84645\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}