{"id":84688,"date":"2018-03-10T00:09:03","date_gmt":"2018-03-10T00:09:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/elementos-reguladores-de-la-fase-g1-del-ciclo-celular\/"},"modified":"2018-03-10T00:09:03","modified_gmt":"2018-03-10T00:09:03","slug":"elementos-reguladores-de-la-fase-g1-del-ciclo-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/elementos-reguladores-de-la-fase-g1-del-ciclo-celular\/","title":{"rendered":"Elementos reguladores de la fase g1 del ciclo celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Sanchez Diaz <\/strong><\/h2>\n<p>Rum1 y sic1 son prote\u00ednas capaces de regular la fase g1 del ciclo celular, ya que son inhibidores de los complejos que forma la quinasa p34(cdc2\/cdc28) con las ciclinas de tipo b. En esta tesis doctoral se demuestra que bajos niveles de expresi\u00f3n de sic1 en schizosaccharomyces pombe rescatan todos los fenotipos asociados a las c\u00e9lulas que carecen del gen rum 1+. Adem\u00e1s, altos niveles del inhibidor sic1 en s.Pombe inducen rondas extras de replicaci\u00f3n del adn sin llevar a cabo la mitosis; este fenotipo es muy similar a la sobreexpresi\u00f3n de rum1+. Tambien, la expresi\u00f3n moderada de rum1+ en sccharomyces cerevisiae recupera la parada en g1 caracter\u00edstica de las c\u00e9lulas cdc4 sic1delta. La sobreexpresi\u00f3n de rum1+ en s. Crevisiae provoca un bloqueo en la fase g1 del ciclo celular, cuyo fenotipo es consistente con la inactivaci\u00f3n de la actividad quinasa asociada a todas las ciclinas de tipo b. Finalmente, hemos estudiado el dominio de rum1+ que interacciona con la ciclina cdc13+e inhibe la acticidad quinasa de los complejos cdk\/ciclina. Este dominio est\u00e1 formado por 80 amino\u00e1cidos que presentan homolog\u00eda con el dominio inhibidor de sic1. Todas estas observaciones sugieren que la prote\u00edna rum1 de s.Pombe y la prote\u00edna sic1 de s.Cerevisiae definen una familia de inhibidores de cdk que regula e forma negativa los complejos ciclinas b\/ckd1 durante la fase g1 del ciclo celular.  cdc10 es un factor de transcripci\u00f3n de s. Pombe que regula la expresi\u00f3n de genes importantes para llevar a cabo la fase s.Hemos clonado un nuevo gen de mam\u00edferos (rat\u00f3n y humano), denominado hbp2, que complementa los mutantes de cdc10. Este nuevo gen codifica una prote\u00edna del tipo hmg que regula de forma positiva la transcripci\u00f3n de algunos genes que dependen de cdc10. Dada la importancia de las prote\u00ednas hmg en procesos de diferenciaci\u00f3n gracias a su capacidad de transcribir genes espec\u00edficos de tejido, proponemos que hbp2 es un nuevo factor de transcri<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Elementos reguladores de la fase g1 del ciclo celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Elementos reguladores de la fase g1 del ciclo celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Sanchez Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sergio Moreno P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pablo Hueso p\u00e9rez <\/li>\n<li>Elena Hidalgo hernando (vocal)<\/li>\n<li>ignacio Paimero rodriguez (vocal)<\/li>\n<li>Jos\u00e9 Ayte del olmo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Sanchez Diaz Rum1 y sic1 son prote\u00ednas capaces de regular la fase g1 del ciclo celular, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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