{"id":84717,"date":"2018-03-10T00:09:03","date_gmt":"2018-03-10T00:09:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-de-la-citogenetica-molecular-al-diagnostico-y-pronostico-del-cancer-de-mama\/"},"modified":"2018-03-10T00:09:03","modified_gmt":"2018-03-10T00:09:03","slug":"contribucion-de-la-citogenetica-molecular-al-diagnostico-y-pronostico-del-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-de-la-citogenetica-molecular-al-diagnostico-y-pronostico-del-cancer-de-mama\/","title":{"rendered":"Contribucion de la citogenetica molecular al diagnostico y pronostico del cancer de mama."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Isabel Zudaire Ripa <\/strong><\/h2>\n<p>El cancer de mama es la segunda causa de muerte en los paises industrializados tras las enfermedades cardiovasculares. A pesar de los numerosos estudios llevados a cabo en esta neoplasia, es necesario todavia la caracterizaci\u00f3n de buenos marcadores pron\u00f3sticos que permitan de forma m\u00e1s precisa la evoluci\u00f3n de las pacientes. En este sentido, las tecnicas de citogen\u00e9tica han contribuido enormemente a aumentar el conocimiento de la biolog\u00eda del tumor.  el objetivo de esta tesis ha sido la caracterizaci\u00f3n de las alteraciones cromos\u00f3micas presentes en una serie de 70 carcinomas de mama de tipo ductal invasivo. La asociaci\u00f3n entre los marcadores citogen\u00e9ticos y la supervivencia e incidencia de recidivas de las pacientes, asi como la asociaci\u00f3n con determinados factores anatomopatol\u00f3gicos nos permitir\u00eda identificar nuevos marcadores con un posible valor pron\u00f3stico.  la tecnica utilizada para ello ha sido la t\u00e9cnica de hibridaci\u00f3n gen\u00f3mica comparada. Fue necesario modificar el protocolo tradicional de esta t\u00e9cnica para obtener resultados satisfactorios en el an\u00e1lisis de tejidos incluidos en parafina.  se obtuvieron resultados satisfactorios en 57 de las 70 muestras seleccionadas (81,4%). Considerando conjuntamente todas las alteraciones descritas en un mismo brazo, las ganancias detectadas con mayor frecuencia afectaron a 8q (63,1%), 17q (45,6%), 1q (38,6%), 20q (26,3%), 11q (21%) y 6q (17,5%) y las perdidas m\u00e1s frecuentes fueron en 16q(21%), de xp y xq (19,3%), 13q(17,5%), 11q(15,7%) y 8p (15,7%).  en el estudio de supervivencia, las ganancias en 1q y 11q13 se mostraron significativamente asociadas a una mayor incidencia de recidivas de las pacientes. Algunas de las alteraciones citogen\u00e9ticas descritas se asociaron significativamente con rasgos de buen pronostico; por ejemplo,las perdidas en 16q fueron m\u00e1s frecuentes en tumores sin infiltraci\u00f3n ganglionar, positivos para la expresi\u00f3n de receptores de estr\u00f3genos y que m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion de la citogenetica molecular al diagnostico y pronostico del cancer de mama.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion de la citogenetica molecular al diagnostico y pronostico del cancer de mama. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Isabel Zudaire Ripa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Calasanz Abinzano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Rivera pomar <\/li>\n<li>Javier Ben\u00edtez ortiz (vocal)<\/li>\n<li>guillermo L\u00f3pez Garc\u00eda (vocal)<\/li>\n<li>Juan  cruz Cigudosa garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Isabel Zudaire Ripa El cancer de mama es la segunda causa de muerte en los paises [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,155,35,9,11771,2820,17749,347],"tags":[9291,7788,13350,49759,178811,32175],"class_list":["post-84717","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-genetica-clinica","category-genetica-humana","category-navarra","category-oncologia-clinica","tag-guillermo-lopez-garcia","tag-javier-benitez-ortiz","tag-jose-maria-rivera-pomar","tag-juan-cruz-cigudosa-garcia","tag-maria-isabel-zudaire-ripa","tag-maria-jose-calasanz-abinzano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84717"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84717\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}