{"id":84753,"date":"2018-03-10T00:09:08","date_gmt":"2018-03-10T00:09:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-interleukina-8-sobre-la-adhesion-celular-y-su-regulacion-implicaciones-en-la-endometriosis\/"},"modified":"2018-03-10T00:09:08","modified_gmt":"2018-03-10T00:09:08","slug":"efecto-de-la-interleukina-8-sobre-la-adhesion-celular-y-su-regulacion-implicaciones-en-la-endometriosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-interleukina-8-sobre-la-adhesion-celular-y-su-regulacion-implicaciones-en-la-endometriosis\/","title":{"rendered":"Efecto de la interleukina-8 sobre la adhesion celular y su regulacion: implicaciones en la endometriosis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Antonio Garcia Velasco <\/strong><\/h2>\n<p>La endometriosis es una enfermedad que ha sido calificada de enigm\u00e1tica por no conocerse a\u00fan su patog\u00e9nesis. De entre todas las teor\u00edas propuestas, la teor\u00eda de la menstruaci\u00f3n retr\u00f3grada propuesta por sampson es la m\u00e1s aceptada. Un microambiente peritoneal alterado que conduce a una inflamaci\u00f3n cr\u00f3nica es, cada vez m\u00e1s, la hip\u00f3tesis que complementa esta teor\u00eda, como lo demuestran los niveles aumentados de citoquinas y factores de crecimiento en el l\u00edquido peritoneal de mujeres con endometriosis. La interleuquina (il)-8 es un citoquina quimiot\u00e1ctica que atrae neutr\u00f3filos y que estimula la angiog\u00e9nesis. Sus niveles aumentados en el l\u00edquido peritoneal de las mujeres con endometriosis hacen sospechar su implicaci\u00f3n en la patog\u00e9nesis de esta enfermedad. Tras describir un modelo in vitro para estudiar la adherencia celular mediante un marcador fluorescentes, hemos visto como la il-8 es capaz de estimular la adherencia de las c\u00e9lulas endometriales a la matriz extracelular. Este efecto es dosis-dependiente. El anticuerpo monoclonal anti-il-8 es capaz de inhibir este efecto parcialmente. Por otro lado investigamos si el propio mecanismo de adherencia estimula la producci\u00f3n de il-8, lo que efectivamente ocurri\u00f3. De todas las prote\u00ednas de la matriz extracelular estudiadas, es la fibronectina la que estimula esta adherencia con mayor intensidad, tanto a nivel de arnm como de prote\u00edna. para buscar si las integrinas-mol\u00e9culas de adhesi\u00f3n celular-estaban implicadas en este mecanismo, estudiamos las subunidades beta 1 y beta 2, comprobando como la subunidad beta 1 estimula con gran intensidad la producci\u00f3n de il-8. La transducci\u00f3n de esta se\u00f1al precisa un citoesqueleto intacto, como lo demuestra  su abolici\u00f3n tras la ruptura de este citoesqueleto con citocalasina. por lo tanto, la il-8 no solo favorece la adhesi\u00f3n del endometrio, sino que la propia adhesi\u00f3n estimula la producci\u00f3n de il-8, potenci\u00e1ndose mutuamente. esta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la interleukina-8 sobre la adhesion celular y su regulacion: implicaciones en la endometriosis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la interleukina-8 sobre la adhesion celular y su regulacion: implicaciones en la endometriosis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Antonio Garcia Velasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Gonzalez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ordas santo-tomas <\/li>\n<li> Alvarez de los heros j.ignacio (vocal)<\/li>\n<li>Antonio Pellicer Martinez (vocal)<\/li>\n<li> Fuente p\u00e9rez pedro de la (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Antonio Garcia Velasco La endometriosis es una enfermedad que ha sido calificada de enigm\u00e1tica por no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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