{"id":84825,"date":"2000-02-06T00:00:00","date_gmt":"2000-02-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-pronostica-de-las-alteraciones-en-los-cromosomas-17-y-18-y-en-el-gen-p53-en-cancer-colorrectal-correlacion-con-otros-factores-pronoticos\/"},"modified":"2000-02-06T00:00:00","modified_gmt":"2000-02-06T00:00:00","slug":"valoracion-pronostica-de-las-alteraciones-en-los-cromosomas-17-y-18-y-en-el-gen-p53-en-cancer-colorrectal-correlacion-con-otros-factores-pronoticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-pronostica-de-las-alteraciones-en-los-cromosomas-17-y-18-y-en-el-gen-p53-en-cancer-colorrectal-correlacion-con-otros-factores-pronoticos\/","title":{"rendered":"Valoracion pronostica de las alteraciones en los cromosomas 17 y 18 y en el gen p53 en cancer colorrectal. correlacion con otros factores pronoticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Duque Alcorta Jos\u00e9 M. <\/strong><\/h2>\n<p>La mutaci\u00f3n del gen p53 y la deleci\u00f3n de los cromosomas 17 y 18 tienen un papel en la carcinog\u00e9nesis colorrectal que a\u00fan no est\u00e1 bien establecido y parecen asociarse con tumores de una mayor agresividad biol\u00f3gica y peor evoluci\u00f3n.  nuestros objetivos fueron estudiar la incidencia de anomal\u00edas cuantitativas de los cromosomas 17 y 18 y el gen p53 determinadas por hibridaci\u00f3n in situ (fish), la ploidia del adn y la proliferaci\u00f3n celular por citometr\u00eda de flujo y la acumulaci\u00f3n de la proteina p53 por inmunohistoquimica y el valor pron\u00f3stico de todos ellos as\u00ed como el de los factores pronosticos clasicos en 78 casos de carcinoma colorrectal intervenidos quirurgicamente en estudios a,b y c de dukes tras un seguimiento de 53 meses (24 meses).  la alteraci\u00f3n cromosomica m\u00e1s frecuente fue la ganancia de copias del cromosoma 17(32 tumores, 41%) y del cromosoma 18 (20 tumores, 25%). Las alteraciones en los cromosomas 17 y 18 y la deleci\u00f3n del gen p53 se asociaron con la aneuploidia, la acumulaci\u00f3n de la proteina p53 y con la localizaci\u00f3n en el colon izquierdo y en el recto.  en el analisis multivariante el estadio de dukes y la invasi\u00f3n de vasos linf\u00e1ticos demostraron un valor pron\u00f3stico en la supervivencia mientras que el estadio de dukes y la acumulacion de proteina p53 fueron factores predictivos de recidiva.  parece que los tumores de colon izquierdo y el recto tienen una via de carcinogenesis diferente que los de colon derecho, pero no hemos observado que sigan una evoluci\u00f3n postquir\u00fargica diferente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoracion pronostica de las alteraciones en los cromosomas 17 y 18 y en el gen p53 en cancer colorrectal. correlacion con otros factores pronoticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoracion pronostica de las alteraciones en los cromosomas 17 y 18 y en el gen p53 en cancer colorrectal. correlacion con otros factores pronoticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Duque Alcorta Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Javier Sola Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Sainz samitier <\/li>\n<li>Mar\u00eda  Jos\u00e9 Calasanz abinzano (vocal)<\/li>\n<li>angel Gomez palacios (vocal)<\/li>\n<li>Miguel Idoate gastearena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Duque Alcorta Jos\u00e9 M. La mutaci\u00f3n del gen p53 y la deleci\u00f3n de los cromosomas 17 y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,155,9,491,139,17749,1027,347,156],"tags":[156084,178976,32344,32175,178977,18028],"class_list":["post-84825","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-clinicas","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-navarra","category-oncologia","category-oncologia-clinica","category-patologia","tag-angel-gomez-palacios","tag-duque-alcorta-jose-m","tag-jesus-javier-sola-gallego","tag-maria-jose-calasanz-abinzano","tag-miguel-idoate-gastearena","tag-ricardo-sainz-samitier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84825"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84825\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}