{"id":84925,"date":"2000-09-06T00:00:00","date_gmt":"2000-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-las-moleculas-de-adhesion-celular-neurales-ncam-durante-el-desarrollo-de-la-astrologia-efecto-del-etanol\/"},"modified":"2000-09-06T00:00:00","modified_gmt":"2000-09-06T00:00:00","slug":"caracterizacion-de-las-moleculas-de-adhesion-celular-neurales-ncam-durante-el-desarrollo-de-la-astrologia-efecto-del-etanol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-las-moleculas-de-adhesion-celular-neurales-ncam-durante-el-desarrollo-de-la-astrologia-efecto-del-etanol\/","title":{"rendered":"Caracterizacion de las moleculas de adhesion celular neurales (ncam) durante el desarrollo de la astrolog\u00eda: efecto del etanol."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mi\u00f1ana Muros Rosa M. <\/strong><\/h2>\n<p>Las mol\u00e9culas de adhesi\u00f3n celular neurales desempe\u00f1an funciones cr\u00edticas durante la migraci\u00f3n neuronal, sinaptog\u00e9nesis y crecimiento ax\u00f3nico, por lo que se las considera mol\u00e9culas morforreguladoras.  en el  presente trabajo, demostramos que durante el periodo neonatal en la rata se expresa psa-ncam o forma polisialilada de ncam. Esta isoforma va desapareciendo a medida que transcurre la maduraci\u00f3n de corteza cerebral y paralelamente comienza a expresarse ncam 180 y ncam 140, con mayores propiedades de adhesi\u00f3n, permitiendo la estabilizaci\u00f3n de la sinapsis. la exposici\u00f3n al etanol durante el desarrollo de cerebro induce: un aumento de psa-ncam una alteraci\u00f3n en la transici\u00f3n a las isoformas maduras y una disminuci\u00f3n en los niveles de ncam 140 al final del periodo postnatal. estos efectos parecen estar mediados por cambios postraduccionales, ya que los arnm de las diferentes isoformas no se afectan por la exposici\u00f3n al etanol. De hecho, los niveles de actividad sialiltransferasa (enzima responsable de la s\u00edntesis de psa-ncam) son menores en cerebros expuestos al etanol.  tambi\u00e9n hemos caracterizado la expresi\u00f3n de ncam en astrocitos en cultivo primario, describiendo por primera vez la presencia de psa-ncam en estas c\u00e9lulas durante su fase de proliferaci\u00f3n, apareciendo localizada en ves\u00edculas citopl\u00e1smicas del aparato de golgi. La diferenciaci\u00f3n de los astrocitos conlleva una desaparici\u00f3n de psa-ncam y ncam 180 y la expresi\u00f3n de ncam 140 localizada en la membrana plasm\u00e1tica y regiones de contacto intercelular. de acuerdo con la expresi\u00f3n temporal de psa-ncam la actividad sialiltransferasa es elevada en la fase de proliferaci\u00f3n y disminuye conforme las c\u00e9lulas se diferencian.  mediante estudios de inmunolocalizaci\u00f3n e inmunoprecipitaci\u00f3n con clatrina y adaptina demostramos que ncam se endocita por una v\u00eda dependiente de clatrina. De acuerdo con estos resultados, psa-ncam y ncam 140 presentan vidas medias la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de las moleculas de adhesion celular neurales (ncam) durante el desarrollo de la astrolog\u00eda: efecto del etanol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de las moleculas de adhesion celular neurales (ncam) durante el desarrollo de la astrolog\u00eda: efecto del etanol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mi\u00f1ana Muros Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Consuelo Guerri Sirera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Vi\u00f1a ribes <\/li>\n<li>Luis Megias megias (vocal)<\/li>\n<li>Jaime Renau piqueras (vocal)<\/li>\n<li>domingo Barettino fraile (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mi\u00f1ana Muros Rosa M. Las mol\u00e9culas de adhesi\u00f3n celular neurales desempe\u00f1an funciones cr\u00edticas durante la migraci\u00f3n neuronal, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,115,35,9,9399,156,17,29602],"tags":[22150,40184,19177,11637,7586,179118],"class_list":["post-84925","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-ciencias-medicas","category-cultivo-celular","category-patologia","category-quimica","category-teratologia","tag-consuelo-guerri-sirera","tag-domingo-barettino-fraile","tag-jaime-renau-piqueras","tag-juan-vina-ribes","tag-luis-megias-megias","tag-minana-muros-rosa-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84925"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84925\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}