{"id":84979,"date":"2018-03-10T00:09:21","date_gmt":"2018-03-10T00:09:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/derivados-bis2-aminoimidazolinio-y-bis-guanidinio-con-actividad-analgesica-alfa-adrenergica-y-frente-a-receptores-de-imidazolina\/"},"modified":"2018-03-10T00:09:21","modified_gmt":"2018-03-10T00:09:21","slug":"derivados-bis2-aminoimidazolinio-y-bis-guanidinio-con-actividad-analgesica-alfa-adrenergica-y-frente-a-receptores-de-imidazolina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/derivados-bis2-aminoimidazolinio-y-bis-guanidinio-con-actividad-analgesica-alfa-adrenergica-y-frente-a-receptores-de-imidazolina\/","title":{"rendered":"Derivados bis(2-aminoimidazolinio) y bis-guanidinio con actividad analgesica, alfa-adrenergica y frente a receptores de imidazolina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Christophe Dardonville <\/strong><\/h2>\n<p>Se describe la s\u00edntesis y la evaluaci\u00f3n farmacol\u00f3gica de una nueva clase de mol\u00e9culas de tipo bis(2-aminoimidazolinio) con actividad analg\u00e9sica y sobre los receptores a-adren\u00e9rgicos y de imidazolina. Se ha desarrollado una nueva aproximaci\u00f3n sint\u00e9tica para la obtenci\u00f3n de derivados 2-ariliminoimidazolidina en disoluci\u00f3n as\u00ed como en fase s\u00f3lida mediante la preparaci\u00f3n de un nuevo anclaje para la s\u00edntesis org\u00e1nica sobre soporte s\u00f3lido. Se ha comprobado a nivel te\u00f3rico, mediante c\u00e1lculos ab initio e \u00edndicescu\u00e1nticos de similitud, la gran semejanza que existe entre los cationes 2-aminoimidazolinio, 2-aminoimidazolio y guanidinio, tanto a nivel de par\u00e1metros geom\u00e9tricos como de propiedades intr\u00ednsecas de la mol\u00e9cula(pem, p), justificando la utilizaci\u00f3n del cati\u00f3n 2-aminoimidazolinio para reemplazar al cati\u00f3n guanidinio en la b\u00fasqueda de nuesvos f\u00e1rmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Derivados bis(2-aminoimidazolinio) y bis-guanidinio con actividad analgesica, alfa-adrenergica y frente a receptores de imidazolina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Derivados bis(2-aminoimidazolinio) y bis-guanidinio con actividad analgesica, alfa-adrenergica y frente a receptores de imidazolina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Christophe Dardonville <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Isabel Rozas Hernando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Plumet ortega <\/li>\n<li>ib\u00f3n Alkorta osoro (vocal)<\/li>\n<li>jean Martinez (vocal)<\/li>\n<li>Mar\u00eda  isabel Martin fontelles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Christophe Dardonville Se describe la s\u00edntesis y la evaluaci\u00f3n farmacol\u00f3gica de una nueva clase de mol\u00e9culas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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