{"id":84982,"date":"2018-03-10T00:09:21","date_gmt":"2018-03-10T00:09:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-antagonistas-de-los-receptores-at1-de-la-angiotensina-ii-sobre-diversas-corrientes-de-salida-de-k-cardiacas-humanas\/"},"modified":"2018-03-10T00:09:21","modified_gmt":"2018-03-10T00:09:21","slug":"efectos-de-los-antagonistas-de-los-receptores-at1-de-la-angiotensina-ii-sobre-diversas-corrientes-de-salida-de-k-cardiacas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-antagonistas-de-los-receptores-at1-de-la-angiotensina-ii-sobre-diversas-corrientes-de-salida-de-k-cardiacas-humanas\/","title":{"rendered":"Efectos de los antagonistas de los receptores at1 de la angiotensina ii sobre diversas corrientes de salida de k+ cardiacas humanas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Caballero Collado <\/strong><\/h2>\n<p>Los f\u00e1rmacos antagonistas de los receptores tipo 1 de la angiotensina ii (araii) se han convertido en los \u00fatlimos a\u00f1os en una de las primeras opciones terp\u00e9uticas en el tratamiento de la hipertensi\u00f3n arterial y la insuficiencia card\u00edaca. El estudio multic\u00e9ntrioco elite demostr\u00f3 que los enfermos con insuficiencia card\u00edaca que eran tratados conel losart\u00e1npresentabanuna menor incidencia de muerte s\u00fabita card\u00edaca que los tratados con captopril. esta disminuci\u00f3n de la mortalidad parec\u00eda ser consecuencia de la reducci\u00f3n en la dispersi\u00f3n del intervalo qtc del electrocardiogrma producido por losart\u00e1n. Estos resultados suger\u00edan que le losart\u00e1n modificaba la velocidad de repolarizaci\u00f3n del potencial de acci\u00f3n card\u00edaco humano. Sin embargo, no exist\u00eda, hasta la fecha, ning\u00fan estudio en el que se anlizaran los efectos de estos f\u00e1rmacos sobre corrientes i\u00f3nicas card\u00edacas.  en la presente tesis doctoral se han estudiado los efectos de cuatro f\u00e1rmacos araii sobre las corrientes de k generadas por canales card\u00edacos clonados de tejido humno. Los f\u00e1rmacos seleccionados fueron: el losart\u00e1n, cabeza de serie del grupo. Los resultados obtenidos demuestran que los cuatro f\u00e1rmacos, a concentraciones del rango terap\u00e9utco, modifican las corrientes de salida de k a trave\u00c2\u00bfs de los canles hkv1,5, herg,kvlqt1+mink y kv4,3. Estas modificaci\u00f3n se presenta en ocasiones como una disminuci\u00f3n de la salida de k y en otros casos el f\u00e1rmaco produce un efecto doble, aumentando o disminuyendo la salida de k a tr\u00e1ves del canala dependiendo del potencial de membrana y de la concentraci\u00f3n del f\u00e1rmaco.  el candesart\u00e1n es el f\u00e1rmaco m\u00e1s potente para bloquear los canales hkv1,5, herg, kvlqt1+mink y kv4,3, por el contrario el e3174 es el que mayor aumento produce de las corrientes hkv1,5 y herg mientras que el eprosart\u00e1n eran el m\u00e1s potente para aumentar la corriente,kvlqt1+mink . Los efectos directos producidos pro losart\u00e1n e3174, esprosar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los antagonistas de los receptores at1 de la angiotensina ii sobre diversas corrientes de salida de k+ cardiacas humanas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los antagonistas de los receptores at1 de la angiotensina ii sobre diversas corrientes de salida de k+ cardiacas humanas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Caballero Collado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eva Delpon Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li>Antonio Rodr\u00edguez artalejo (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<li> Diez Martinez domingo Francisco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Caballero Collado Los f\u00e1rmacos antagonistas de los receptores tipo 1 de la angiotensina ii (araii) se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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