{"id":8500,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/tratamiento-citostatico-del-carcinoma-no-microcitico-avanzado-de-pulmon\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"tratamiento-citostatico-del-carcinoma-no-microcitico-avanzado-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-citostatico-del-carcinoma-no-microcitico-avanzado-de-pulmon\/","title":{"rendered":"Tratamiento citostatico del carcinoma no microcitico avanzado de pulmon."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Garcia Giron <\/strong><\/h2>\n<p>Se analizan las caracteristicas pronosticas y su relacion con la respuesta al tratamiento, con la duracion de la respuesta objetiva, con la supervivencia y los largos supervivientes de una serie de 518 enfermos con cancer no microcitico avanzado de pulmon tratados con diversas combinaciones de quimioterapia, la mayoria incluyen cisplatino, a traves de 10 ensayos en fase ii, realizados desde 1979 a 1993.La tasa de respuesta objetiva a la quimioterapia es del 31%, con un 4% de respuestas completas. Las caracteristicas relacionadas con la obtencion de respuesta son: ecog 0-1, no perdida de peso, ldh normal, enfermedad localizada, no metastasis hepaticas ni suprarrenales y no mas de una localizacion metastasica. Las combinaciones de citostaticos mas activas son: mip (mitomicina, ifosfamida, cisplatino), pvd (cisplatino, vindesina) y pvp (cisplatino, etoposido) con un 35-40% de respuesta objetiva. La mediana de duracion de la respuesta objetiva es de 6 meses. Los factores relacionados con una mayor duracion son: ecog 0-1, enfermedad localizada, respuesta completa y tratamiento con mip, pvd y pvp.  la mediana de supervivencia es de 8,8 meses y los factores relacionados con una mayor supervivencia son:  ecog 0-1, ldh normal y enfermedad localizada. El 32% de los enfermos vive un a\u00f1o o mas, y los factores relacionados son ecog 0-1, enfermedad localizada y respuesta objetiva a la quimioterapia.  la toxicidad es muy moderada en frecuencia e intensidad con un 6% de neutopenia grado 3-4, 17% de nauseas y vomitos grado 3-4, y neurotoxicidad grado 1-2 en el 15% de los enfermos. Solo hay 5 (1%) muertes toxicas.  por tanto, los enfermos con cancer de pulmon no microcitico avanzado con buen estado general y poca masa tumoral en forma de extension de la enfermedad y valor de la ldh son tributarios de beneficio con tratamiento citostatico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento citostatico del carcinoma no microcitico avanzado de pulmon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento citostatico del carcinoma no microcitico avanzado de pulmon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Garcia Giron <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel G\u00f3nzalez Bar\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  Sancho Martin <\/li>\n<li> Gonz\u00e1lez Larriba Jos\u00e9 Luis (vocal)<\/li>\n<li>Mar\u00eda  Luisa Garcia De Paredes Perez De Sevilla (vocal)<\/li>\n<li>Alfredo Moyano Jato (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Garcia Giron Se analizan las caracteristicas pronosticas y su relacion con la respuesta al tratamiento, con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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