{"id":85015,"date":"2018-03-10T00:09:25","date_gmt":"2018-03-10T00:09:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-expresion-de-cd44-por-splicing-alternativo-y-su-implicacion-en-neoplasias-humanas\/"},"modified":"2018-03-10T00:09:25","modified_gmt":"2018-03-10T00:09:25","slug":"mecanismos-de-expresion-de-cd44-por-splicing-alternativo-y-su-implicacion-en-neoplasias-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-expresion-de-cd44-por-splicing-alternativo-y-su-implicacion-en-neoplasias-humanas\/","title":{"rendered":"Mecanismos de expresion de cd44 por splicing alternativo y su implicacion en neoplasias humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Roca Castella F. Xavier <\/strong><\/h2>\n<p>Las isoformas de cd44 se originan por mecanismos de splicing alternativo de la regi\u00f3n central (exones v2-v10) de su pre-mrna. En el primer bloque del trabajo se ha utilizado el carcinoma de mama humana como modelo para describir las vias de splicing alternativo que actuan en esta regi\u00f3n ,las cuales explican el conjunto de isoformas de cd44 expresadas en este tejido. la via general de splicing alternativo induce la exclusi\u00f3n de los exones de la regi\u00f3n variable en sentido 5\u00c2\u00bf-3\u00c2\u00bf,dirigi\u00e9ndose a la sintesis de cd44h, exenta de exones variables. Este sistema aparece desregulado en el carcinoma, ya que se observa la inclusi\u00f3n gradual y progresiva de los exones de 3\u00c2\u00bfa 5\u00c2\u00bf, y a la aparici\u00f3n de isoformas de mayor peso molecular. Es un efecto posicional, correspondiente a un mecanismo de control de splicing alternativo que podr\u00eda ser compartido por otros genes implicados en met\u00e1stasis. La segunda via promueve la inclusi\u00f3n del ex\u00f3n variable 3, y se mantiene en ambos casos, fisiol\u00f3gico y patol\u00f3gico. En el segundo bloque de la tesis se describe el uso de nuevos splice sites 3\u00c2\u00bfde los exones variables 5 y 7 del cd44, fen\u00f3meno que confiere mayor variabilidad a la prote\u00edna. El tercer bloque aborda una primera aproximaci\u00f3n a la caracterizaci\u00f3n de los elementos cis-reguladores de la inclusi\u00f3n espec\u00edfica del ex\u00f3n variable 3 del cd44 en el tejido mamario humano. Se ha visto que la longitud de los intrones flanqueantes de v3 es un determinante de la exclusi\u00f3n mayoritaria de este ex\u00f3n en el mrna, y se han acotado las posiciones de almenos dos enhancers de splicing de v3.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de expresion de cd44 por splicing alternativo y su implicacion en neoplasias humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de expresion de cd44 por splicing alternativo y su implicacion en neoplasias humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Roca Castella F. Xavier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcos Isamat Riviere<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pujol borrell <\/li>\n<li>gabriel Capella munar (vocal)<\/li>\n<li>pablo Engel rocamora (vocal)<\/li>\n<li>daniel Grinberg vaisman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roca Castella F. Xavier Las isoformas de cd44 se originan por mecanismos de splicing alternativo de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[42605,33983,107172,34391,13791,179241],"class_list":["post-85015","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-daniel-grinberg-vaisman","tag-gabriel-capella-munar","tag-marcos-isamat-riviere","tag-pablo-engel-rocamora","tag-ricardo-pujol-borrell","tag-roca-castella-f-xavier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85015"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85015\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}