{"id":85029,"date":"2018-03-10T00:09:25","date_gmt":"2018-03-10T00:09:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunohistoqua%c2%admico-y-morfologico-en-ojos-de-pacientes-con-sindrome-de-sja%c2%b6gren\/"},"modified":"2018-03-10T00:09:25","modified_gmt":"2018-03-10T00:09:25","slug":"estudio-inmunohistoqua%c2%admico-y-morfologico-en-ojos-de-pacientes-con-sindrome-de-sja%c2%b6gren","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-inmunohistoqua%c2%admico-y-morfologico-en-ojos-de-pacientes-con-sindrome-de-sja%c2%b6gren\/","title":{"rendered":"Estudio inmunohistoqu\u00edmico y morfologico en ojos de pacientes con sindrome de sj\u00c1\u00b6gren."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Oroza Alonso M. Antonia <\/strong><\/h2>\n<p>El estudio pretende, en primer lugar, establecer un protocolo de laboratorio para diagnosticar lo m\u00e1s precoz, fiable y sensiblemente el s\u00edndrome de sj\u00ed\u00b6gren (ss). En segundo lugar, establecer la especificidad y sensibilidad de las pruebas, patognom\u00f3nica y estad\u00edsticamente. Y, en tercer lugar, evaluar la evoluci\u00f3n de la enfermedad y la bondas del tratamiento.  el estudio se realiz\u00f3 en 33 pacientes con ss. Como controles participar\u00f3n 33 pacientes con qcs no sist\u00e9mica y 33 personas sanas. A todos ellos se les realizaronuna historia cl\u00ednica integrada, pruebas con biomicroscop\u00eda, pruebas cl\u00ednicas (prueba de schirmer, tinci\u00f3n conrosa de bengala y tiempo de ruptura de la pelicual lagrimal), pruebas de laboratorio (proteinograma de la l\u00e1grima, cristalizaci\u00f3n de la l\u00e1grima, cultivo microbiol\u00f3gico ocular y osmolaridad de la l\u00e1grima), t\u00e9cnicas inmunol\u00f3gicas sericas y gammagraf\u00eda de las gl\u00e1ndulas par\u00f3tidas, citometr\u00eda de flujo y t\u00e9cnicas morfol\u00f3gicas (citolog\u00eda de impresi\u00f3n, biopsia conjuntival, biopsia de las gl\u00e1ndulas lagrimales y salivales menores). A las biopsias conjuntivales se les realizaronestudios morfol\u00f3gicos, inmunohistoqu\u00edmicos e inmunofluorescencia directa.  los anticuerpos anti-ssa, anti-ssb, aans, fr, el alelo hla-dr3, los linfocitos t cd4 y b, las queratinas ae3 y ae10, la hsp27 y el vip mostraron diferencias signficativas entre los pacientes con ss, los pacientes conqcs y las personas sanas. La citolog\u00eda de impresi\u00f3n conjuntival y las biopsias de la conjuntiva gl\u00e1ndula lagrimal y salibales menores presentaron tambi\u00e9n diferencias significativas en el el ss y los dos grupos controles, as\u00ed como entre los pacientes con ss tratados y sin tratamiento.  todo esto nos permite concluir que la causa del da\u00f1o ocasionado por el ss en nuestrso pacientes estuvo mediada simult\u00e1neamente por citotoxidad celular y por un componenete humoral, con una marcada predisposici\u00f3n gen\u00e9tica y endocrina. Por ello, consider<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunohistoqu\u00edmico y morfologico en ojos de pacientes con sindrome de sj\u00c1\u00b6gren.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunohistoqu\u00edmico y morfologico en ojos de pacientes con sindrome de sj\u00c1\u00b6gren. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Oroza Alonso M. Antonia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Rivas Jara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li>adolfo Toledano (vocal)<\/li>\n<li> Morube de castillo Juan (vocal)<\/li>\n<li>eduardo Garcia poblete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oroza Alonso M. Antonia El estudio pretende, en primer lugar, establecer un protocolo de laboratorio para diagnosticar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,155,35,9,848,2008,988],"tags":[179261,3237,20539,85025,179262,179260],"class_list":["post-85029","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-citologia","category-morfologia-celular","category-oftalmologia","tag-adolfo-toledano","tag-benjamin-fernandez-ruiz","tag-eduardo-garcia-poblete","tag-luis-rivas-jara","tag-morube-de-castillo-juan","tag-oroza-alonso-m-antonia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85029"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85029\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}