{"id":85073,"date":"2018-03-10T00:09:29","date_gmt":"2018-03-10T00:09:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-patogenicos-implicados-en-la-toxicidad-gastrointestinal-de-ketoprofeno-y-sus-enantiomeros-en-rata\/"},"modified":"2018-03-10T00:09:29","modified_gmt":"2018-03-10T00:09:29","slug":"mecanismos-patogenicos-implicados-en-la-toxicidad-gastrointestinal-de-ketoprofeno-y-sus-enantiomeros-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-patogenicos-implicados-en-la-toxicidad-gastrointestinal-de-ketoprofeno-y-sus-enantiomeros-en-rata\/","title":{"rendered":"Mecanismos patog\u00e9nicos implicados en la toxicidad gastrointestinal de ketoprofeno y sus enanti\u00f3meros en rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Nieto Masa Ana Isabel <\/strong><\/h2>\n<p>Ketoprofeno es un aine quiral cuyo enanti\u00f3mero s es el activo frente a cox, si bien levoketoprofeno no est\u00e1 exento de provocar reacciones adversas, por lo que recientemente se ha comercializado dexketoprofeno puro.  nos propusimos valorar la influencia de la quiralidad en la incidencia y severidad del da\u00f1o gastrointestinal inducido por ketoprofeno rac\u00e9mico y sus enanti\u00f3meros en modelos de ulcerog\u00e9nesis aguda y cr\u00f3nica en ratas, as\u00ed como tratar de dilucidar los mecanismos implicados en la gastroenteropat\u00eda.  el estudio experimental se realiz\u00f3 invivo con animal entero, y las determinaciones bioqu\u00edmicas se llevaron a cabo principalmente por t\u00e9cnicas espectrofotom\u00e9tricas e inmunol\u00f3gicas.  los resultados obtenidos inducen a confirmar las ventajas de la utilizaci\u00f3n de enanti\u00f3meros puros de aine quirales, al observarse una menor gastrolesividad tras el tratamiento con dexketoprofeno en relaci\u00f3n al compuesto rac\u00e9mico, en todos los modelos experimentales. Adem\u00e1s el levois\u00f3mero present\u00f3 una mayor toxicidad gastrointestinal que su ant\u00edpoda \u00f3ptica.  las lesiones g\u00e1stricas inducidas por las mol\u00e9culas en estudio parecen tener un origen isqu\u00e9mico estando implicados los radicales libres derivados del ox\u00edgeno. Por el contrario, las lesiones intestinales provocadas por los compuestos m\u00e1s enterot\u00f3xicos(racemato y enanti\u00f3mero r) poseen un componente inflamatorio con la participaci\u00f3n de neutr\u00f3filos. Adem\u00e1s dichas mol\u00e9culas provocan la reducci\u00f3n de los mecanismos antioxidantes celulares, hecho que puede contribuir a la etipopatogenia del da\u00f1o.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos patog\u00e9nicos implicados en la toxicidad gastrointestinal de ketoprofeno y sus enanti\u00f3meros en rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos patog\u00e9nicos implicados en la toxicidad gastrointestinal de ketoprofeno y sus enanti\u00f3meros en rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Nieto Masa Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Catalina Alarcon De La Lastra Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Alcudia gonzalez <\/li>\n<li>elisa Marhuenda requena (vocal)<\/li>\n<li>Luis Bravo diaz (vocal)<\/li>\n<li>francesc Cabre vacas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nieto Masa Ana Isabel Ketoprofeno es un aine quiral cuyo enanti\u00f3mero s es el activo frente a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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