{"id":85092,"date":"2018-03-10T00:09:29","date_gmt":"2018-03-10T00:09:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-biofarmaceutico-y-farmacocinetico-de-ciclosporina-a-en-sistemas-coloidales-multiparticulares\/"},"modified":"2018-03-10T00:09:29","modified_gmt":"2018-03-10T00:09:29","slug":"estudio-biofarmaceutico-y-farmacocinetico-de-ciclosporina-a-en-sistemas-coloidales-multiparticulares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-biofarmaceutico-y-farmacocinetico-de-ciclosporina-a-en-sistemas-coloidales-multiparticulares\/","title":{"rendered":"Estudio biofarmac\u00e9utico y farmacocin\u00e9tico de ciclosporina a en sistemas coloidales multiparticulares."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Chacon Garces <\/strong><\/h2>\n<p>El objetivo fundamental del trabajo ha consistido en la evaluaci\u00f3n biofarmac\u00e9utica y farmacocin\u00e9tica de formas de dosificai\u00f3n nano (np) y micropart\u00edculas (mp) de ciclosporina a (cya), elaboradas con dos pol\u00edmeros biodegradables: \u00e1cidopolil\u00e1ctico-glic\u00f3lico (plga) y poli-e-caprolactona (pecl).  desde el punto de vista biofarmac\u00e9utico, se analizaron las cin\u00e9ticas de liberaci\u00f3n in vitro de las formulaciones objeto de estudio, compar\u00e1ndolas con dos formulaciones comerciales de referencia. Desde el farmacocin\u00e9tico, se estudiaron los procesos de distribuci\u00f3n, metabolismo y eliminaci\u00f3n de la cya administrada en forma libre, por v\u00eda endovenosa, rtas wistar machos y hembras. As\u00ed mismo se realiz\u00f3 un estudio comparativo de los procesos adme despu\u00e9s de la administraci\u00f3n por v\u00eda oral de las formulaciones estudiadas y las de referencia a los animales de experimentaci\u00f3n, compar\u00e1ndose as\u00ed mismo la biodisponibilidad del f\u00e1rmaco.  finalmente, se llevaron a cabo correlaciones in vitro\/in vivo entre los datos de los estudios de liberaci\u00f3n y los datos farmacocin\u00e9ticos.  los resultados obtenidos permiten concluir que la cya presenta una variabilidad farmacocin\u00e9tica asociada al sexo y la edad de los animales de experimentaci\u00f3n, tanto por v\u00eda iv como por v\u00eda oral. Por lo que respecta a los transportadores estudiados,las np y mp de pecl y plga permiten encapsular una elevada cantidad de cya que se libera a distinta velocidad seg\u00fan el tamam\u00f1o del transportador y del tipo de pol\u00edmero. La administraci\u00f3n in vivo de dichos sistemas iguala o mejora de forma ostensible alguna de las caracter\u00edsticas farmacocin\u00e9ticas de la cya, aunque aparentemente no reduce la variabilidad ni minimiza el efecto del sexo sobre el comportamiento farmacocin\u00e9tico del f\u00e1rmaco libre. la relaci\u00f3n entre el abc y la dosis es lineal cuando la administraci\u00f3n se realiza bajo la forma de np de pecl a diferencia de los que ocurre con la formulaci\u00f3n de referen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio biofarmac\u00e9utico y farmacocin\u00e9tico de ciclosporina a en sistemas coloidales multiparticulares.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio biofarmac\u00e9utico y farmacocin\u00e9tico de ciclosporina a en sistemas coloidales multiparticulares. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Chacon Garces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Guzm\u00e1n Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Sell\u00e9s flores <\/li>\n<li>irene teresa Molina  Martinez (vocal)<\/li>\n<li>Antonio Rabasco alvarez (vocal)<\/li>\n<li>Mar\u00eda  dolores Torres l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Chacon Garces El objetivo fundamental del trabajo ha consistido en la evaluaci\u00f3n biofarmac\u00e9utica y farmacocin\u00e9tica de 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