{"id":8510,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/neuropatologia-cuantitativa-y-epidemiologia-molecular-en-la-enfermedad-de-alzheimer\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"neuropatologia-cuantitativa-y-epidemiologia-molecular-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/neuropatologia-cuantitativa-y-epidemiologia-molecular-en-la-enfermedad-de-alzheimer\/","title":{"rendered":"Neuropatolog\u00eda cuantitativa y epidemiolog\u00eda molecular en la enfermedad de alzheimer."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Teresa Gomez Isla <\/strong><\/h2>\n<p>En la enfermedad de alzheimer (ea) existe, desde el punto de vista anatomopatologico una gran perdida de neuronas en el area 28 de brodmann y en la circunvolucion temporal media, que se encuentra, por el contrario, ausente en el proceso de envejecimiento fisiologico. Dicha perdida neuronal avanza en paralelo con la duracion y progresion clinica de la enfermedad. En las mismas areas el acumulo de ovillos neurofibrilares se correlaciona con la perdida de neuronas, si bien esta ultima desborda sorprendentemente al numero de ovillos. Por el contrario, el porcentaje de corteza cerebral ocupada por placas seniles en las mismas regiones, tiende a permanecer estable independientemente de la duracion de la demencia y de la perdida neuronal.  la frecuencia del alelo e4 del gen que codifica para la apolipoproteina e es tres veces superior en la enfermedad de alzheimer de inicio tardio que en la poblacion general. La herencia de dicho alelo se asocia a una edad de inicio mas temprana de la enfermedad y a un deposito de material amiloide en el cerebro significativamente mayor. La presencia de dicho alelo no guarda, sin embargo, relacion con una evolucion clinica posterior mas acelerada ni con el numero de ovillos neurofibrilares acumulados.  estos hallazgos sugieren que el deposito de material amiloide en forma de placas seniles en la enfermedad de alzheimer podria jugar un papel etiopatogenico en los estadios mas iniciales de la enfermedad, representando la degeneracion neurofibrilar y la perdida neuronal los sustratos anatomopatologicos primarios subyacentes a los deficits clinicos que caracterizan a esta enfermedad. La ausencia de una perdida neuronal significativa en las regiones estudiadas en el envejecimiento fisiologico separa nitidamente a este proceso de la enfermedad de alzheimer y demuestra que este tipo de patolog\u00eda no representa simplemente un proceso de envejecimiento acelerado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuropatolog\u00eda cuantitativa y epidemiolog\u00eda molecular en la enfermedad de alzheimer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuropatolog\u00eda cuantitativa y epidemiolog\u00eda molecular en la enfermedad de alzheimer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Teresa Gomez Isla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Justo Garc\u00eda  De Y\u00e9benes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando Valdivieso Amate <\/li>\n<li>Ana Cabello Ruiz (vocal)<\/li>\n<li>Jes\u00fas Avila De Grado (vocal)<\/li>\n<li>F\u00e9lix Bermejo Pareja (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Teresa Gomez Isla En la enfermedad de alzheimer (ea) existe, desde el punto de vista anatomopatologico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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