{"id":8511,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/regulacion-cis-y-trans-de-los-genes-proneurales-achaete-y-scute-caracterizacion-molecular-del-gen-iroquois\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"regulacion-cis-y-trans-de-los-genes-proneurales-achaete-y-scute-caracterizacion-molecular-del-gen-iroquois","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-cis-y-trans-de-los-genes-proneurales-achaete-y-scute-caracterizacion-molecular-del-gen-iroquois\/","title":{"rendered":"Regulacion cis y trans de los genes proneurales achaete y scute. caracterizacion molecular del gen iroquois."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Gomez Skarmeta <\/strong><\/h2>\n<p>Los genes achaete (ac) y scute (sc) se regulan a nivel cis por elementos tipo enhancers localizados a lo largo de 90 kb del complejo achaete-scute (c-as). Estos enhancers dirigen la expresion de ac y sc en grupos proneurales especificos del disco imaginal de ala. Alguno de los enhancers parecen estar repetidos en mas de una region del c-as. Los enhancers parecen responder a combinaciones especificas de trans reguladores, elementos del prepatron. Un posible elemento del prepatron es el gen iroquois (iro). Iro codifica un factor de transcripcion que posee un homeodominio y es responsable de la activacion de ac y sc en determinados grupos proneurales. El homeodominio de iro es similar al de la proteina extradenticle. La proteina iro es capaz de unirse \u00abin vitro\u00bb al enhancer l3\/tsm del c-as a una secuencia que tiene el consenso de union de la mayoria de las homeoproteinas (taat). Esta secuencia y las colindantes estan altamente conservadas en el c-as de drosophila virilis. La sustitucion de la secuencia de union de iro al enhancer l3\/tsm suprime su capacidad \u00abin vivo\u00bb de activar la transcripcion en los grupos proneurales l3 y tsm. La sobreexpresion de iro es capaz de activar ectopicamente, pero solo en determinadas regiones del disco de ala, a los genes ac y sc. Esto indica que existen otros factores que colaboran con iro en la activacion de ac y sc. La sobreexpresion de iro es capaz de reorganizar el patron de venas, alterar la morfolog\u00eda del borde del ala y reducir el tama\u00f1o de esta.  concluyendo, iro es un factor de transcripcion del prepatron capaz de activar la transcripcion de ac y sc actuando a traves de algunos enhancers del c-as, y posiblemente colaborando con otros factores. Ademas, esta posiblemente implicado en la formacion del patron de venas y en otros procesos como proliferacion y\/o muerte celular y diferenciacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion cis y trans de los genes proneurales achaete y scute. caracterizacion molecular del gen iroquois.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion cis y trans de los genes proneurales achaete y scute. caracterizacion molecular del gen iroquois. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Gomez Skarmeta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Modolell Mainou<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia Bellido <\/li>\n<li>Ana Vazquez (vocal)<\/li>\n<li>Gines Morata Perez (vocal)<\/li>\n<li>Francisco Murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Gomez Skarmeta Los genes achaete (ac) y scute (sc) se regulan a nivel cis por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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