{"id":85120,"date":"2018-03-10T00:09:33","date_gmt":"2018-03-10T00:09:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-galenico-de-una-solucion-oral-de-fosfato-de-codeina\/"},"modified":"2018-03-10T00:09:33","modified_gmt":"2018-03-10T00:09:33","slug":"desarrollo-galenico-de-una-solucion-oral-de-fosfato-de-codeina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-galenico-de-una-solucion-oral-de-fosfato-de-codeina\/","title":{"rendered":"Desarrollo galenico de una solucion oral de fosfato de codeina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M Rosa Franqueza Garcia <\/strong><\/h2>\n<p>Tras un estudio de preformulaci\u00f3n se ha conseguido elaborar una soluci\u00f3n oral de fosfato de code\u00edna exenta de alcohol y sacarosa apta p-ara determinados grupos de pacientes, como diab\u00e9ticos, ancianos y ni\u00f1os, con unas caracter\u00edsticas farmacot\u00e9cnicas y organol\u00e9pticas \u00f3ptimas, que presenta una serie de mejoras con respecto a las preparaciones antitusivas actualmente comercializadas.  los m\u00e9todos desarrollados para la identificaci\u00f3n y valoraci\u00f3n del principio activo, fosfato de codeina hemihidrato y del conservante antimicrobiano, benzoato de sodio han sido validados, al igual que el m\u00e9todo de fabricaci\u00f3n.   con la formulaci\u00f3n seleccionada tras la fase de preformulaci\u00f3n, se ha realizado un amplio estudio de estabilidad seg\u00fan las directrices de estabilidad que marcan las ich para envases semipermeables, en condiciones de alta temperatura y baja humedad relativa. Adem\u00e1s se han realizado dichos estudios en varios tipos de acondicionamiento primario, seleccion\u00e1ndose el vidrio topacio y los pl\u00e1sticos, pet y polietileno de alta densidad, tambi\u00e9n se ha estudiado la influencia de distintos cierres en dichos envases, como tapas met\u00e1licas de  aluminio y de seguridad \u00abpresionar y girar\u00bb, para aumentar la seguridad pasiva de la soluci\u00f3n oral de code\u00edna desarrollada.  de todos los envases estudiados, el acondicionamiento primario de elecci\u00f3n para nuestra soluci\u00f3n oral de code\u00edna es el envase de vidrio topacio con tapa child-proof (presionar y girar). En el envase de pet, la formulaci\u00f3n sufre un proceso de permeaci\u00f3n a trav\u00e9s del envase, sufriendo cambios que afectan a su calidad final, al igual que en el pehd.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo galenico de una solucion oral de fosfato de codeina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo galenico de una solucion oral de fosfato de codeina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M Rosa Franqueza Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alvaro Acebron Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>Mar\u00eda  Jos\u00e9 Garcia sanchez (vocal)<\/li>\n<li>Mar\u00eda  rosa Jimenez castellanos (vocal)<\/li>\n<li>marina Herraez dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M Rosa Franqueza Garcia Tras un estudio de preformulaci\u00f3n se ha conseguido elaborar una soluci\u00f3n oral de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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