{"id":85125,"date":"2018-03-10T00:09:33","date_gmt":"2018-03-10T00:09:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-oxido-nitrico-por-los-macrofagos-alveolares-en-la-toxocariosis-experimental\/"},"modified":"2018-03-10T00:09:33","modified_gmt":"2018-03-10T00:09:33","slug":"produccion-de-oxido-nitrico-por-los-macrofagos-alveolares-en-la-toxocariosis-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/produccion-de-oxido-nitrico-por-los-macrofagos-alveolares-en-la-toxocariosis-experimental\/","title":{"rendered":"Produccion de oxido nitrico por los macr\u00f3fagos alveolares en la toxocariosis experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Espinoza Saavedra Elsa Yolanda <\/strong><\/h2>\n<p>En esta tesis doctoral la hip\u00f3tesis de trabajo fue de toxocara canis utiliza, entre sus mecanismos de evasi\u00f3n, la producci\u00f3n de on por las c\u00e9lulas del sistema mononuclear fagoc\u00edtico.  lo primero que se hizo fue evaluar el efecto de diferentes concentraciones de los ant\u00edgenos excretores\/secretores y som\u00e1tico de adultos y de larvas lii de toxocara canis sobre la producci\u00f3n de \u00f3xido n\u00edtrico(on) en los macr\u00f3fagos alveolares de rata.  los resultados mostraron que los ant\u00edgenos som\u00e1ticos de lii y los ant\u00edgenos excretores\/secretores de vermes adultos eran capaces de inducir la producci\u00f3n de on. En ambos casos la producci\u00f3n de este mediador inflamatorio fue concentraci\u00f3n dependiente. El efecto de estos ant\u00edgenos se ejerci\u00f3 a nivel transcripcional. igualmente los ant\u00edgenos excretores\/secretores de adulto de toxocara canis estimularon la producci\u00f3n de prostaglandinas e2 por macr\u00f3fagos alveolares de rata a nivel transcripcional, estando mediado el proceso parcialmente por on.  tambi\u00e9n se observ\u00f3 que la principal v\u00eda de se\u00f1alizaci\u00f3n intracitoplasm\u00e1tica utilizada por los ant\u00edgenos de toxocara canis para estimular la producci\u00f3n de on en macr\u00f3fagos alveolares de rata, es la que emplea \u00e1cido araquid\u00f3nico y sus productos. En esta parte del trabajo se utilizaron como sustancias inhibidores de las v\u00edas de se\u00f1alizaci\u00f3n intracitoplasm\u00e1tica lic1, verapamillo, tmb-8, estaurosporina, mepacrina,dec y meloxicam.  adem\u00e1s se comprob\u00f3 que el on no ejerc\u00eda efectos t\u00f3xicos sobre las larvas lii (fase infectante) del par\u00e1sito en experimentos \u00abin vitro\u00bb,en los que se utilizaron como donadores del on los compuestos sin-1(3-morfolinosignonimina) y snog(s-nitroso l-glutation).  finalmente al estudiar el efecto de la inhibici\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible en un modelo de toxocariosis experimental, se encontr\u00f3 que la utilizaci\u00f3n de aminoguanidina(sustancia inhibidora de la enzima) reduc\u00eda en ratas de lesiones ocasi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Produccion de oxido nitrico por los macr\u00f3fagos alveolares en la toxocariosis experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Produccion de oxido nitrico por los macr\u00f3fagos alveolares en la toxocariosis experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Espinoza Saavedra Elsa Yolanda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Muro \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  ramon Martinez fernandez <\/li>\n<li>basilio Valladares hernandez (vocal)<\/li>\n<li>Luis San rom\u00e1n del barrio (vocal)<\/li>\n<li>Miguel Cordero sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Espinoza Saavedra Elsa Yolanda En esta tesis doctoral la hip\u00f3tesis de trabajo fue de toxocara canis utiliza, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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