{"id":85171,"date":"2018-03-10T00:09:37","date_gmt":"2018-03-10T00:09:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-gabaergic-de-les-neurones-serotonergiques-dels-nuclis-del-rafe\/"},"modified":"2018-03-10T00:09:37","modified_gmt":"2018-03-10T00:09:37","slug":"control-gabaergic-de-les-neurones-serotonergiques-dels-nuclis-del-rafe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/control-gabaergic-de-les-neurones-serotonergiques-dels-nuclis-del-rafe\/","title":{"rendered":"Control gabaergic de les neurones serotonergiques dels nuclis del rafe."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Teresa Abellan Vidal <\/strong><\/h2>\n<p>La serotonina (5-ht) ha sido involucrada en la sintomatolog\u00eda de diferentes transtornos y enfermedades del sistema nervioso central, lo que explica la utilizaci\u00f3n creciente de farmacos con acci\u00f3n serotonin\u00e9rgica en la pr\u00e1ctica clinica diaria. El objetivo principal de esta tesis ha sido profundizar en el conocimiento del control de las neurones serotonin\u00e9rgicas por la neurotransmisi\u00f3n gaba\u00e9rgica, enfatizando en el papel de los receptores gaba b. Este estudio se ha llevado a cabo en una doble vertiente. Por una parte se ha analizado la regulaci\u00f3n de la actividad serotonin\u00e9rgica en la v\u00eda n\u00facleo dorsal del rafe. Por otra parte se han estudiado los neurotransmisores implicados en el control de la liberaci\u00f3n de 5-ht en el cuerpo estriado. el procedimiento mayoriario empleado ha sido la microdi\u00e1lisis intracerebral in vivo, pero tambi\u00e9n se han realizado experimentos de electrofisiolog\u00eda y de hibridaci\u00f3n in situ. Las conclusiones fundamentales de este trabajo se resumen as\u00ed:  -la neurotransmisi\u00f3n gaba\u00e9rgica ejerce un control complejo sobre las neuronas sertonin\u00e9rgicas del n\u00facleo dorsal del rafe (ndr), de manera que el efecto final de la estimulaci\u00f3n de los receptores gaba b  a ese nivel es el balance entre dos acciones: una acci\u00f3n directa, postsin\u00e1ptica, inhibitoria, a nivel de los cuerpos de las neuronas 5-ht y otra acci\u00f3n indirecta, presin\u00e1tpica, desinhibitoria, a nivel de terminaciones inhibitorias que llegan a las neuronas 5-ht. El agonista gaba b r(+) baclofen muestra una acci\u00f3n preferente sobre los receptores presin\u00e1pticos.  -este agonista produce una mayor desinhibici\u00f3n de los neuronas del ndr que sobre las del n\u00facleo medial del rafe (nmr) dado que el teono gaba\u00e9rgico es mayor en el primero.  -los experimentos de hibridaci\u00f3n in situ han mostrado la presencia del rna mensajero del gaba b r1 en las neuronas 5-ht de ambos n\u00facleos del rafe.  -a pesar de la importancia de las transmisi\u00f3n gaba\u00e9rgica en el c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control gabaergic de les neurones serotonergiques dels nuclis del rafe.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control gabaergic de les neurones serotonergiques dels nuclis del rafe. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Teresa Abellan Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Artigas P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>cristina Su\u00f1ol esquirol (vocal)<\/li>\n<li>roser Cortes colome (vocal)<\/li>\n<li>eduardo Tolosa sarr\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Teresa Abellan Vidal La serotonina (5-ht) ha sido involucrada en la sintomatolog\u00eda de diferentes transtornos y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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