{"id":85173,"date":"2018-03-10T00:09:37","date_gmt":"2018-03-10T00:09:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-crono-farmaceutico-de-metamizol-2-gr-via-oral-en-pacientes-con-dolor-cronico-por-patologia-neoplasica\/"},"modified":"2018-03-10T00:09:37","modified_gmt":"2018-03-10T00:09:37","slug":"estudio-crono-farmaceutico-de-metamizol-2-gr-via-oral-en-pacientes-con-dolor-cronico-por-patologia-neoplasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-crono-farmaceutico-de-metamizol-2-gr-via-oral-en-pacientes-con-dolor-cronico-por-patologia-neoplasica\/","title":{"rendered":"Estudio crono farmace\u00fatico de metamizol 2 gr. via oral en pacientes con dolor cr\u00f3nico por  patolog\u00eda neopl\u00e1sica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Sanchez Ana M. <\/strong><\/h2>\n<p>En el presente estudio se eval\u00faa un posible comportameinto circadiano de los par\u00e1metros faracocin\u00e9ticos de 2g. De metamizol adminsitrado por v\u00eda oral en 20 pacietes de ambos sexos con dolor cr\u00f3nico porpatolog\u00eda neopl\u00e1sica preferiblemente con met\u00e1stasis \u00f3seas. As\u00ed mismo estudiamos una posble interacci\u00f3n entre los niveles de b-endorfinas y metamizol y el efecto analg\u00e9sico.  la intensidad del dolor en la escala anal\u00f3gica visual (vas) de los pacientes deb\u00eda ser superior a 50 mm. En el momento de inclusi\u00f3n en el estudio.  a todos los pacientes se les adminsitr\u00f3 una dosis oral de 2 g. De metamizol a las 8 de las ma\u00f1ana del 1er. Dia para establecer la garmacocin\u00e9tica diurna y a las 6 de la tarde del 3er. Dia para establecer la famacocin\u00e9tica nocturna, permitiendo un per\u00edodo de aclaramiento entre dosis de 34 horas.  se extrajeron muestras de sangre en los tiempos previamente establecidos; antes de la adminsitraci\u00f3n del f\u00e1rmaco, a los 10, 20 y 30 minutos y a la 1,2,3,4,5,6,8,12,23 y 24 horas despu\u00e9s de la toma, para determinar los niveles de matabolitos de metamizol (maa, aa, aaa) y los nivles de b-endorfinas.  no encontramos diferencias estadisticamente significtaivas en los par\u00e1metros famacocim\u00e9ticos \u00e1rea bajo la curva (auc), concentraci\u00f3nm\u00e1xima (max) y semivida de eliminaci\u00f3n (t1\/2) en ninguno d elos metabolitos de metamizol tras la adminsitraci\u00f3n diurna o nocturna del mismo. El proceso de eliminaci\u00f3n parece ser m\u00e1s lento tras la adminsitraci\u00f3n nocturna aunque sin diferencias significativas. por otro lado, tampoco encontramos una correlaci\u00f3n clara entre la intensidad del dolor referida por los pacientes y los niveles de b-endornfinas.  el tratamiento con 2g. De metamiz via oral fue bien tolerado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio crono farmace\u00fatico de metamizol 2 gr. via oral en pacientes con dolor cr\u00f3nico por  patolog\u00eda neopl\u00e1sica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio crono farmace\u00fatico de metamizol 2 gr. via oral en pacientes con dolor cr\u00f3nico por  patolog\u00eda neopl\u00e1sica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Sanchez Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Clemente Muriel Villoria<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Palanca san Francisco <\/li>\n<li> Gonzalez gonzalez Juan  Antonio (vocal)<\/li>\n<li>Juan Gonzalez machado (vocal)<\/li>\n<li> Ortega martin-corral Luis Emilio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Sanchez Ana M. En el presente estudio se eval\u00faa un posible comportameinto circadiano de los par\u00e1metros [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1569,9,141,2445,957,9386],"tags":[9871,179497,9612,8550,172385,58044],"class_list":["post-85173","post","type-post","status-publish","format-standard","hentry","category-anestesiologia-quirurgica","category-ciencias-medicas","category-cirugia","category-evaluacion-de-farmacos","category-farmacologia","category-salamanca","tag-clemente-muriel-villoria","tag-garcia-sanchez-ana-m","tag-gonzalez-gonzalez-juan-antonio","tag-jose-maria-palanca-san-francisco","tag-juan-gonzalez-machado","tag-ortega-martin-corral-luis-emilio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85173"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85173\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}