{"id":85203,"date":"2018-03-10T00:09:37","date_gmt":"2018-03-10T00:09:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-entre-los-sistemas-gab-ergico-y-dopaminergico-en-modelos-animales-de-agresion-y-catalepsia\/"},"modified":"2018-03-10T00:09:37","modified_gmt":"2018-03-10T00:09:37","slug":"estudio-de-la-interaccion-entre-los-sistemas-gab-ergico-y-dopaminergico-en-modelos-animales-de-agresion-y-catalepsia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-interaccion-entre-los-sistemas-gab-ergico-y-dopaminergico-en-modelos-animales-de-agresion-y-catalepsia\/","title":{"rendered":"Estudio de la interaccion entre los sistemas gab-ergico y dopaminergico en modelos animales de agresion y catalepsia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Carmen Pedraza Benitez <\/strong><\/h2>\n<p>Tras el descubrimiento del gaba los primeros estudios sobre sus funciones biol\u00f3gicas no pudieron llevarse a cabo que era incapaz de atravesar la barrera hematoencefalogr\u00e1fica. En un intento por buscar un compuesto an\u00e1logo laborit sintetiz\u00f3 en 1964 el \u00e1cido gamma-hidroxibut\u00edrico(ghb). Poco tiempo despu\u00e9s se comprob\u00f3 que esta sustancia estaba presente de modo natural en el sistema nervioso de los mam\u00edferos, postul\u00e1ndose que posiblemente actuase como un neurotransmisor.  se han descrito una gran cantidad de efectos cl\u00ednicos y conductuales inducidos de la administraci\u00f3n de ghb. En este sentido, ha sido empleado por el tratamiento de los trastornos del sue\u00f1o, como modelo animal de crisis de ausencia, para mejorar el metabolismo energ\u00e9tico e incluso para el tratamiento del s\u00edndrome de abstinencia al alcohol y a los opi\u00e1ceos.  aunque poco tiempo despu\u00e9s de su descubrimiento se postul\u00f3 que posiblemente actuase como un modulador del sistema dopamin\u00e9rgico cerebral. Su papel regulador sobre este sistema de neurotransmisi\u00f3n es poco conocido y los resultados de experimentales resultan confusos. Teniendo en cuenta todos estos datos, el objetivo de la tesis ha sido estudiar la interacci\u00f3n entre el sistema ghbergico y dopamin\u00e9rgico utilizando para ello modelos animales de agresi\u00f3n y de catalepsia. Para llevar a cabo los objetivos se han dise\u00f1ado un total de 7 experimentos enlos que se ha examinado el efecto de la coadministraci\u00f3n de ghb con agonistas y antagonistas de los receptores d1 y d2 sobre las citadas conductas. Igualmente se ha evaluado el efecto de la adminsitraci\u00f3n subcr\u00f3nica de ghb. Los resultados experimentales sugieren la existencia de una interacci\u00f3n entre los sistemas ghb\u00e9rgicos y dopamin\u00e9rgicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interaccion entre los sistemas gab-ergico y dopaminergico en modelos animales de agresion y catalepsia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interaccion entre los sistemas gab-ergico y dopaminergico en modelos animales de agresion y catalepsia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Carmen Pedraza Benitez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Navarro Humanes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Segovia vazquez <\/li>\n<li>Jos\u00e9 Pav\u00eda molina (vocal)<\/li>\n<li>Alberto Morales moreno (vocal)<\/li>\n<li>Ana Adan  puig (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Carmen Pedraza Benitez Tras el descubrimiento del gaba los primeros estudios sobre sus funciones biol\u00f3gicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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