{"id":85212,"date":"2018-03-10T00:09:37","date_gmt":"2018-03-10T00:09:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-del-sitema-hla-en-poblacion-vasca\/"},"modified":"2018-03-10T00:09:37","modified_gmt":"2018-03-10T00:09:37","slug":"polimorfismos-del-sitema-hla-en-poblacion-vasca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/polimorfismos-del-sitema-hla-en-poblacion-vasca\/","title":{"rendered":"Polimorfismos del sitema hla en poblaci\u00f3n vasca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Fern\u00e1ndez Garc\u00eda <\/strong><\/h2>\n<p>La poblaci\u00f3n vasca debido a sus particulares caracter\u00edsticas gen\u00e9ticas, ling\u00ed\u00bcisticas y socioculturales, ha sido sustrato de numerosos estudios. el objetivo de este trabajo es ayudar a caracterizar gen\u00e9ticamente a la poblaci\u00f3n vasca mediante el estudio de los polomorfismos del sistema hla. este sistema hla es un sitema antig\u00e9nico leucocitariocuyos genes se sit\u00faan en el brazo corto del cromosoma 6 formando junto con otros el complejo mayor de histocompatibilidad humano (cmh). Posee el polomorfismo m\u00e1s elevado de los descritos en la especie humana y adem\u00e1s los alelos se trasmiten en bloques o haplotipos por lo que es muy \u00fatil en estudios de gen\u00e9tica poblacional.  se han analizado 93 individuos sanos no emparentados residentes en el pa\u00eds vasco con al menos 4 apellidos vascos y con su origen familiar confirmado hasta al menos la 3\u00aa generaci\u00f3n. Es el estudio se ha realizado utilizando t\u00e9cnicas serol\u00f3gicas y de biolog\u00eda molecular pcr-sso, hibridaci\u00f3n inversa y pcr-ssp para el tipaje de los loci hla clase i (a,b y c) y de clase ii (dbr, dqa y dqb).  se han calculado las frecuencias fenot\u00edpicas, g\u00e9nicas, desequilibrios del ligamiento y distancias gen\u00e9ticas entre la poblaci\u00f3n vasca y otras poblaciones considerando diferentes \u00e1mbitos geogr\u00e1ficos como son poblaciones lcoales, europeas, caucasoides y por \u00faltimo de europa, asia y africa. Sobre este conjunto de datos se han aplicado procedimientos uni y multivariantes para poder analizar con mayor profundidad la estructura gen\u00e9tica.  se observa una total correspondencia entre las t\u00e9cnicas de biolog\u00eda molecular y una mejor definici\u00f3n de los alelos respecto a a las t\u00e9cnicas serol\u00f3gicas.La mayor cantidad de informaci\u00f3n se obtiene analizando de manera conjunta todas las especificidades con alta resoluci\u00f3n con el mayor n\u00famero de poblaciones, obteniendo una elevada concordancia con las distribuci\u00f3n geogr\u00e1fica de las supoblaciones y en relaci\u00f3n con las poblaciones locale<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos del sitema hla en poblaci\u00f3n vasca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos del sitema hla en poblaci\u00f3n vasca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Fern\u00e1ndez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Masdevall M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosario Calderon fernandez <\/li>\n<li>alfonso Sanchez ibarrola (vocal)<\/li>\n<li>jaume Martorell pons (vocal)<\/li>\n<li>guadalupe Ercilla gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Fern\u00e1ndez Garc\u00eda La poblaci\u00f3n vasca debido a sus particulares caracter\u00edsticas gen\u00e9ticas, ling\u00ed\u00bcisticas y socioculturales, ha sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[922,35,299,1737,12909],"tags":[13420,99760,179550,1374,20470,6672],"class_list":["post-85212","post","type-post","status-publish","format-standard","hentry","category-antropologia-fisica","category-ciencias-de-la-vida","category-genetica-antropologica","category-inmunologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alfonso-sanchez-ibarrola","tag-esther-fernandez-garcia","tag-garcia-masdevall-m-dolores","tag-guadalupe-ercilla-gonzalez","tag-jaume-martorell-pons","tag-rosario-calderon-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85212"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85212\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}