{"id":85333,"date":"2018-03-10T00:09:45","date_gmt":"2018-03-10T00:09:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-anoxia-sobre-la-inhibicion-farmacologica-de-la-interaccionplaqueta-subendotelio\/"},"modified":"2018-03-10T00:09:45","modified_gmt":"2018-03-10T00:09:45","slug":"efecto-de-la-anoxia-sobre-la-inhibicion-farmacologica-de-la-interaccionplaqueta-subendotelio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-anoxia-sobre-la-inhibicion-farmacologica-de-la-interaccionplaqueta-subendotelio\/","title":{"rendered":"Efecto de la anoxia sobre la inhibicion farmacologica de la interaccionplaqueta-subendotelio."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez Vicente M. Dolores <\/strong><\/h2>\n<p>En la mayor\u00eda de los estudios sobre f\u00e1rmacos antitromb\u00f3ticos, se utilizan unas condiciones de oxigenaci\u00f3n normal, pero el ambiente cl\u00ednico en el que estos medicamentos se utilizan existe un estado de anoxia. El objetivo del presente estudio es valorar la influencia que la falta de ox\u00edgeno puediera tener sobre el efecto de algunos antiagregantes plaquetarios enla interacci\u00f3n de la plaqueta conel subendotelio vascular.  el estudi\u00f3 se realiz\u00f3 en condiciones in vitro, valor\u00e1ndose t\u00e9cnicas de agregometr\u00eda en sangre total, producci\u00f3n de tromboxano y cuantifiaci\u00f3n morfol\u00f3gica de la interacci\u00f3nplaqueta-subendotelio en condiciones de flujo. aspirian redujo su efecto antitromb\u00f3tico en situaci\u00f3n de anoxia, hecho que tambi\u00e9n se observ\u00f3 contriglusal y ticlopidina.  el metabolito del triflusal, htb y el dipiridamol no modificaron su efecto en situaci\u00f3n de anoxia ni tras reoxigener a la muestra despu\u00e9s de la anoxia. En general los f\u00e1rmacos que actuan a trav\u00e9s de una inhibici\u00f3n de la s\u00edntesis de tromboxano son los m\u00e1s afectado en situaci\u00f3n de baja concentraci\u00f3n de ox\u00edgeno, mientras que aquellos que utilizan los nucle\u00f3tidos c\u00edclicos como mecanismo de acci\u00f3n no ven modificado su efecto en esta situaci\u00f3n.  dipiridamol, debido a su efecto antioxidante, incluso incrementa su acci\u00f3n antitromb\u00f3tica tras la reoxigenaci\u00f3n de las muestras sangu\u00edneas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la anoxia sobre la inhibicion farmacologica de la interaccionplaqueta-subendotelio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la anoxia sobre la inhibicion farmacologica de la interaccionplaqueta-subendotelio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez Vicente M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cruz Cortesj Ose Pedro De La<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Smith agreda Jos\u00e9 M\u00aa <\/li>\n<li>mercedes Zabaleta meri (vocal)<\/li>\n<li>Antonio Hevia alonso (vocal)<\/li>\n<li>pablo Salinas s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez Vicente M. Dolores En la mayor\u00eda de los estudios sobre f\u00e1rmacos antitromb\u00f3ticos, se utilizan unas condiciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,7834,483],"tags":[26651,179739,11858,7912,179738,173703],"class_list":["post-85333","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-malaga","category-mecanismos-de-accion-de-los-farmacos","tag-antonio-hevia-alonso","tag-cruz-cortesj-ose-pedro-de-la","tag-mercedes-zabaleta-meri","tag-pablo-salinas-sanchez","tag-perez-vicente-m-dolores","tag-smith-agreda-jose-ma"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85333"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85333\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}