{"id":85337,"date":"2018-03-10T00:09:45","date_gmt":"2018-03-10T00:09:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-actividad-de-los-receptores-de-estrogenos-en-el-cancer-de-mama\/"},"modified":"2018-03-10T00:09:45","modified_gmt":"2018-03-10T00:09:45","slug":"regulacion-de-la-actividad-de-los-receptores-de-estrogenos-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-de-la-actividad-de-los-receptores-de-estrogenos-en-el-cancer-de-mama\/","title":{"rendered":"\u00abregulaci\u00f3n de la actividad de los receptores de estr\u00f3genos en el c\u00e1ncer de mama\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan a Mar\u00eda Garcia Pedrero <\/strong><\/h2>\n<p>El inter\u00e9s de este trabajo se centra en la b\u00fasqueda y caracterizaci\u00f3n de nuevas estrategias para la regulaci\u00f3n y el control de la actividad de los receptores de estr\u00f3genos en lineas celulares de c\u00e1ncer de mama re+). para ello nos planteamos los siguientes objetivos:  1. La caracterizaci\u00f3n funcional de la variante del re    carente del ex\u00f3n 7(re e7)cuya expresi\u00f3n es mayoritaria en c\u00e9lulas mcf-7 de carcinoma de mama humano(re+),con el fin de establecer la capacidad de esta forma truncada de receptor para actuar como dominante-negativo, antagonizando la actividad transcripcional dependiente de ligando de re y\/o re  .  2. El estudio de la acci\u00f3n de la melatonina(cuya acci\u00f3n inhibidora sobre la actividad estrog\u00e9nica hab\u00edamos postulado que podr\u00eda deberse a su capacidad de antagonizar la funci\u00f3n de la calmodulina) y del w7 un antagonista de la calmodulina bien caracterizado. Hemos evaluado sus capacidades como antagonistas selectivos de la respuesta mediada por re  y\/o re    en diferentes promotores. Nuestros resultados parecen indicar que tanto la melatonina como la calmodulina inhiben el re    y no el re   . De confirmarse este hecho, se podr\u00eda pensar en la generaci\u00f3n de nuevos mser (moduladores selectivos del receptor de estr\u00f3genos) potencialmente utilizables en el tratamiento de tumores mamarios (re+).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abregulaci\u00f3n de la actividad de los receptores de estr\u00f3genos en el c\u00e1ncer de mama\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abregulaci\u00f3n de la actividad de los receptores de estr\u00f3genos en el c\u00e1ncer de mama\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan a Mar\u00eda Garcia Pedrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sofia Ramos Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>Ana Aranda iriarte (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>mercedes Villalobos torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan a Mar\u00eda Garcia Pedrero El inter\u00e9s de este trabajo se centra en la b\u00fasqueda y caracterizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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