{"id":85343,"date":"2018-03-10T00:09:45","date_gmt":"2018-03-10T00:09:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-funcional-de-adrenoceptores-alfa-2-en-el-sistema-nervioso-central-de-rata-tras-modificacion-de-la-neurotransmision-noradrenergica\/"},"modified":"2018-03-10T00:09:45","modified_gmt":"2018-03-10T00:09:45","slug":"evaluacion-funcional-de-adrenoceptores-alfa-2-en-el-sistema-nervioso-central-de-rata-tras-modificacion-de-la-neurotransmision-noradrenergica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-funcional-de-adrenoceptores-alfa-2-en-el-sistema-nervioso-central-de-rata-tras-modificacion-de-la-neurotransmision-noradrenergica\/","title":{"rendered":"Evaluaci\u00f3n funcional de adrenoceptores alfa 2 en el sistema nervioso central de rata tras modificaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Prieto D\u00edez <\/strong><\/h2>\n<p>En este estudio, mediante dos abordajes funcionales, la inhibici\u00f3n de la s\u00edntesis de noradrenalina (na) inducida por clonidina y la disminuci\u00f3n de la liberaci\u00f3n del neurotransmisor promovida por oximetazolina, respuestas ambas mediadas por la activaci\u00f3n de adrenoceptores a2 (ar a2), se ha valorado la modulaci\u00f3n de dichos receptores en diversas regiones cerebrales de rta tras modificaciones de la neurotransmisi\u00f3n noradren\u00e9rgic inducidas por diversos tratamientos farmacol\u00f3gicos y por la exposici\u00f3n a varios protocolos de estr\u00e9s.  tanto el tratamiento agudo (24h) como cr\u00f3nico (14d) con el inhibidor de la mao-a. Clorogilina (2 mg\/kg, i.P), reduce la actividad in vivo de la tirosina hidroxilasa (th) en hipocampo, corteza parietal e hipot\u00e1lamo. a pesar del incremento en el contenido de na que se produce tras ambos tratamientos en las tres regiones cerebrales analizadas, \u00fanicamente el tratamiento cr\u00f3nico con clorigilina, conlleva desensibilizaci\u00f3n de los ara2 que regulan la s\u00edntesis y liberaci\u00f3n de na.  a los 21 d\u00edas de la administraci\u00f3n dspa4 (50 mg\/kg, i.P.) Existe un importante descenso del contenido de na y de la actividad th in vivo en las dos regiones cerebrales, hipocampo y corteza parietal, cuya inervaci\u00f3n noradren\u00e9rgica procede mayoritariamente del locus coeruleus.En el hipot\u00e1lamo la actividad th no se modifica.Despu\u00e9s de la inyecci\u00f3n de la neurotoxina, en hipocampo se observa una relevante p\u00e9rdida de la fucionalidad de los ar a2 que regulan la s\u00edntesis y liberaci\u00f3n de na, mientras que en corteza parietal se determina una atenuaci\u00f3n de la respeusta funcional y en hipot\u00e1lamo se mantiene sin cambios la sensibilidad de los ar a2.  el descenso enla funcionalidad de los ar a2 que regulan la liberaci\u00f3n de na determinado encorteza parietal de animales que recibieron el tratamiento cr\u00f3nico con clorogilina, que se inici\u00f3 7 d\u00edas despu\u00e9s de una dosis de dsp4, parece ser debido fundamentalmente a la acci\u00f3n de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n funcional de adrenoceptores alfa 2 en el sistema nervioso central de rata tras modificaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n funcional de adrenoceptores alfa 2 en el sistema nervioso central de rata tras modificaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Prieto D\u00edez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Teresa Giralt Ru\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Pazos carro <\/li>\n<li>victoria Clos guill\u00e9n (vocal)<\/li>\n<li>Luisa Ugedo urruela (vocal)<\/li>\n<li> Lafuente s\u00e1nchez Jos\u00e9 vicente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Prieto D\u00edez En este estudio, mediante dos abordajes funcionales, la inhibici\u00f3n de la s\u00edntesis de noradrenalina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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