{"id":85423,"date":"2018-03-10T00:09:53","date_gmt":"2018-03-10T00:09:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adoptosis-en-el-carcinoma-de-mama-relacion-con-la-expresion-de-bcl-2-p-53-e-indice-de-proliferacion\/"},"modified":"2018-03-10T00:09:53","modified_gmt":"2018-03-10T00:09:53","slug":"adoptosis-en-el-carcinoma-de-mama-relacion-con-la-expresion-de-bcl-2-p-53-e-indice-de-proliferacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/adoptosis-en-el-carcinoma-de-mama-relacion-con-la-expresion-de-bcl-2-p-53-e-indice-de-proliferacion\/","title":{"rendered":"Adoptosis en el carcinoma de mama: relacion con la expresion de bcl-2, p-53 e indice de proliferacion"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Galera Ruiz M. Rosa <\/strong><\/h2>\n<p>En el c\u00e1ncer de mama se ha tratado, debido a su alta incidencia y efectivas estrategias terap\u00e9uticas, de buscar con denuedo factores pron\u00f3sticos que faciliten la confecci\u00f3n de mejores protocolos terap\u00e9uticos.  el estadio ganglionar, el grado histol\u00f3gico y el tama\u00f1o tumoral son factores pron\u00f3sticos \u00fatiles pero insuficientes, ya que los resultados obtenidos aplicando protocolos oncol\u00f3gicos de tratamiento son muy heterog\u00e9neos. La tasa de recidivas y\/o met\u00e1stasis en pacientes con ganglios negativos alcanza hasta el 30%. La existencia de micromet\u00e1stasis axilares, no diagnosticadas en el estudio rutinario de las adenopat\u00edas, y la posible existencia de subpoblaciones tumorales debida a la inestabilidad gen\u00e9tica de los tumores, son algunas de las causas que pueden explicar estos fracasos del tratamiento.  se ha investigado en el presente trabajo la expresi\u00f3n de marcadores de la proliferaci\u00f3n celular(ant\u00edgeno de proliferaci\u00f3n celular ki-67), y de muerte celular (c\u00e9lulas en apoptosis, prote\u00edna bcl-2 y prote\u00edna p-53) con el fin de conocer su influencia en el pron\u00f3stico de la enfermedad a corto plazo y de buscar asociaciones con los factores pron\u00f3stico de la enfermedad a corto plazo y de buscar asociaciones con los factores pron\u00f3sticos cl\u00e1sicos, tales como tama\u00f1o tumoral, edad, grado histol\u00f3gico, estado de receptores y evoluci\u00f3n de la enfermedad.  las principales conclusiones obtenidas son: la expresi\u00f3n de re es la variable con mayor significado pron\u00f3stico y se asocia con el indice de mitosis, grado histol\u00f3gico, indice de ki-67 y expresi\u00f3n de bcl-2. La expresi\u00f3n de prote\u00edna p-53 se asocia exclusivamente con el grado histol\u00f3gico. El \u00edndice de apoptosis tambi\u00e9n muestra relaci\u00f3n con el grado histol\u00f3gico, pero los tumores con bajo indice tienden a ser lesiones menores de 3 cm. que expresan receptores de estr\u00f3genos y suelen ser de escasa actividad proliferativa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adoptosis en el carcinoma de mama: relacion con la expresion de bcl-2, p-53 e indice de proliferacion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adoptosis en el carcinoma de mama: relacion con la expresion de bcl-2, p-53 e indice de proliferacion <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Galera Ruiz M. Rosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Gonzalez Campora<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Matilla vicente <\/li>\n<li>Juan  Jos\u00e9 Sanchez carrillo (vocal)<\/li>\n<li>Antonio Lopez  mu\u00f1oz (vocal)<\/li>\n<li>Jos\u00e9 ram\u00f3n Armas padr\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Galera Ruiz M. Rosa En el c\u00e1ncer de mama se ha tratado, debido a su alta incidencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,156,10715],"tags":[7890,1713,179873,11083,26540,11092],"class_list":["post-85423","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-patologia","category-sevilla","tag-alfredo-matilla-vicente","tag-antonio-lopez-munoz","tag-galera-ruiz-m-rosa","tag-jose-ramon-armas-padron","tag-juan-jose-sanchez-carrillo","tag-ricardo-gonzalez-campora"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85423"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85423\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}