{"id":85436,"date":"2018-03-10T00:09:53","date_gmt":"2018-03-10T00:09:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cinetica-y-factores-predictivos-de-respuesta-al-tratamiento-combinado-de-interferon-alfa-mas-ribavirina-en-pacientes-con-hepatitis-cronica-c-recidivantes-o-no-respondedores-al-interferon\/"},"modified":"2018-03-10T00:09:53","modified_gmt":"2018-03-10T00:09:53","slug":"cinetica-y-factores-predictivos-de-respuesta-al-tratamiento-combinado-de-interferon-alfa-mas-ribavirina-en-pacientes-con-hepatitis-cronica-c-recidivantes-o-no-respondedores-al-interferon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cinetica-y-factores-predictivos-de-respuesta-al-tratamiento-combinado-de-interferon-alfa-mas-ribavirina-en-pacientes-con-hepatitis-cronica-c-recidivantes-o-no-respondedores-al-interferon\/","title":{"rendered":"Cinetica y factores predictivos de respuesta al tratamiento combinado de interferon alfa mas ribavirina en pacientes con hepatitis cronica c recidivantes o no respondedores al interferon."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Moreno Monteagudo Jos\u00e9 Andres <\/strong><\/h2>\n<p>Objetivos: evaluar la eficacia, cin\u00e9tica de respuesta y la seguridad de la asociaci\u00f3n de interferon (ifn) m\u00e1s ribavirina (rib) en el tratamiento de los pacientes con hcc no respondedores (nr) a una pauta previa con ifn s\u00f3lo o bien con recidiva (rec) tras la misma.  pacientes y metodos: a 62 pacientes (42 nr y 20 con rec tras usar ifn) se les administr\u00f3 durante 12 meses ifn alfa-2b (3 mu 3v\/sem) m\u00e1s rib (1-1.2 g\/d\u00eda oral). Todos presentaban alt elevada y arn-vhc positivo en suero, y una biopsia con lesiones de hepatitis cr\u00f3nica activa (evaluada por iah de knodell). El genotipo viral (inno-lipa hcv) m\u00e1s com\u00fan fue el 1b (66.7%). se realizaron ex\u00e1menes cl\u00ednicos y anal\u00edticos (con viremia cuantitativa: amplicor, roche) durante (meses 0, 1, 2, 3, 6 y 12) y despu\u00e9s (meses 3 y 6) del tratamiento. Se defini\u00f3 la respuesta al final del tratamiento (rft) y la respuesta sostenida (rs) cuando se apreci\u00f3 alt normal y arn-vhc negativo al finalizar el tratamiento y a los 6 meses de seguimiento. Tami\u00e9n se analizaron la cin\u00e9tica de respuesta, posibles factores de respuesta favorable al tratamiento (incluyendo el n\u00famero de mutaciones en la regi\u00f3n ns5a), cambios con el tratamiento del \u00e1cido hialur\u00f3nico (ah) s\u00e9rico (marcador indirecto de fibrog\u00e9nesis hep\u00e1tica), y la tolerancia a la medicaci\u00f3n. Como estudio estad\u00edstico se utiliz\u00f3 la t de student y la chi cuadrado, tomando<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cinetica y factores predictivos de respuesta al tratamiento combinado de interferon alfa mas ribavirina en pacientes con hepatitis cronica c recidivantes o no respondedores al interferon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cinetica y factores predictivos de respuesta al tratamiento combinado de interferon alfa mas ribavirina en pacientes con hepatitis cronica c recidivantes o no respondedores al interferon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Moreno Monteagudo Jos\u00e9 Andres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Moreno Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Pajares Garc\u00eda Jos\u00e9 Mar\u00eda <\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero quesada (vocal)<\/li>\n<li>gerardo Clemente ricote (vocal)<\/li>\n<li>Fernando Gonzalez mateos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Moreno Monteagudo Jos\u00e9 Andres Objetivos: evaluar la eficacia, cin\u00e9tica de respuesta y la seguridad de la asociaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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