{"id":85483,"date":"2018-03-10T00:09:57","date_gmt":"2018-03-10T00:09:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunologia-de-la-dirofilariosis-cardiopulmonar-felina-marcadores-de-diagnostico-temprano\/"},"modified":"2018-03-10T00:09:57","modified_gmt":"2018-03-10T00:09:57","slug":"inmunologia-de-la-dirofilariosis-cardiopulmonar-felina-marcadores-de-diagnostico-temprano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inmunologia-de-la-dirofilariosis-cardiopulmonar-felina-marcadores-de-diagnostico-temprano\/","title":{"rendered":"Inmunolog\u00eda de la dirofilariosis cardiopulmonar felina: marcadores de diagnostico temprano"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Prieto Maza M. Guadalupe <\/strong><\/h2>\n<p>La dirofilariosis felina tiene algunas caracter\u00edsticas que hacen dif\u00edcil la detecci\u00f3n de d. Immitis en los gatos. Por otra parte, no existen datos sobre la respuesta de anticuerpos que estos desarrolla contra el par\u00e1sito.  la parte experimental de la memoria se ha divido en 6 estudios:  1. Inicialmente se pusieron a punto m\u00e9todos de elisa con ant\u00edgenos som\u00e1tico(sa) y excretor\/secretor e(s) de vermes adultos y som\u00e1tico de l3(sl3). Analizando sueros de gatos infectados experimentalmente se detectaron niveles moderados de anticuerpos igg contra el sl3 al mes post-infecci\u00f3n(m.P.I.), Descendiendo inmediatamente a niveles basales. Anticuerpos contra los sa y e\/s se detectaron a partir de los 2 m.P.I., Siendo m\u00e1ximo el incremento entre los 2 y los 4 m.P.I. Posteriormente, los niveles tienden a estabilizarse. Cuarente y cinco d\u00edas despu\u00e9s de retirados los vermes a trav\u00e9s de la yugular, las iggs cayeron por debajo de los l\u00edmites de positividad establecidos previamente, en un gato infectado naturalmente.  2. Los elisas puestos a punto en el estudio anterior, permitieron la detecci\u00f3n de anticuerpos a los 2 m.P.I.Y fueron capaces de identificar la acci\u00f3n terape\u00fatica de un macrofilaricida a los 3 meses post-tratamiento, en infecciones experimentales.  3. Empleando western blot se identificaron marcadores moleculares de 19,22,26,30 y 40 kda en el sa y de 22 y 25 kda en el e\/s. Posteriormente se analiz\u00f3 la reactividad de dichos marcadores en diferentes fases de la infecci\u00f3n empleando la misma t\u00e9cnica.  4. Se aislaron fracciones enriquecidas que conten\u00edan los marcadores identificados, mediante cromatograf\u00eda de gel filtraci\u00f3n e intercambio ani\u00f3nico. La fracci\u00f3n f1 conten\u00eda las mol\u00e9culas de 20-28 kda y la fracci\u00f3n f7 la de 30 kda. Estas fracciones se aplicaron en elisa y su capacidad diagn\u00f3stica fue evaluada. la fracci\u00f3n f7 posee una excelente capacidad de diagn\u00f3stico precoz (2 m.P.I.), que mejora en casi 1 mes la de otro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunolog\u00eda de la dirofilariosis cardiopulmonar felina: marcadores de diagnostico temprano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunolog\u00eda de la dirofilariosis cardiopulmonar felina: marcadores de diagnostico temprano <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Prieto Maza M. Guadalupe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Simon Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Antonio Rojo vazquez <\/li>\n<li>claudio Bandi (vocal)<\/li>\n<li>ignacio Navarrete l\u00f3pez-c\u00f3zar (vocal)<\/li>\n<li> De la fuente freyre j. Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Prieto Maza M. Guadalupe La dirofilariosis felina tiene algunas caracter\u00edsticas que hacen dif\u00edcil la detecci\u00f3n de d. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,1737,661,1775,9386,226],"tags":[179961,179962,85978,3216,10993,179960],"class_list":["post-85483","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-inmunologia","category-parasitologia-animal","category-reaccion-antigeno-anticuerpo","category-salamanca","category-zoologia","tag-claudio-bandi","tag-de-la-fuente-freyre-j-antonio","tag-fernando-simon-martin","tag-francisco-antonio-rojo-vazquez","tag-ignacio-navarrete-lopez-cozar","tag-prieto-maza-m-guadalupe"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85483"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85483\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}