{"id":85507,"date":"2018-03-10T00:09:57","date_gmt":"2018-03-10T00:09:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-del-carcinoma-infiltrante-de-mama-sin-afectacion-ganclionar-axilar\/"},"modified":"2018-03-10T00:09:57","modified_gmt":"2018-03-10T00:09:57","slug":"factores-pronosticos-del-carcinoma-infiltrante-de-mama-sin-afectacion-ganclionar-axilar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-pronosticos-del-carcinoma-infiltrante-de-mama-sin-afectacion-ganclionar-axilar\/","title":{"rendered":"Factores pron\u00f3sticos del carcinoma infiltrante de mama sin afectaci\u00f3n ganclionar axilar."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Josefa Herrera De La Muela <\/strong><\/h2>\n<p>Se realiza un estudio de los factores pron\u00f3sticos del carcinoma infiltrante de mama sin afectaci\u00f3n ganglionar axilar en una poblaci\u00f3n de 483 pacientes intervenidas en la maternidad de la paz de Madrid, que procedende todo el territorio espa\u00f1ol.Se incluyen en el estudio 50 variables predictivas. adem\u00e1s de factores pron\u00f3sticos cl\u00e1sicos (cl\u00ednicos, diagn\u00f3sticos, terap\u00e9uticos, biol\u00f3gicos y patol\u00f3gicos),se a\u00f1aden par\u00e1metros inmunohistoqu\u00edmicos novedosos como el oncog\u00e9n c-erb-b2, la prote\u00edna p53, la catepsina d, el pcna y la caderina e. Algunos de estos par\u00e1metros no hab\u00edan sido descritos anteriormente en pacientes con c\u00e1ncer de mama con ganglios negativos.  se realiza en primer lugar el an\u00e1lisis univariante en el que se valora la influencia de cada factor en la supervivencia libre de enfermedad y en la supervivencia global. Posteriormente se analiza la relaci\u00f3n de los factores pron\u00f3sticos entre s\u00ed para determinar qu\u00e9 factores son independientes en la predicic\u00f3n del pron\u00f3stico, mediante un an\u00e1lisis multivariante (modelo de regresi\u00f3n de cox).  dentro del an\u00e1lisis univariante, los par\u00e1metros que incluyen significativamente en la supervivencia libre de enfermedad son: el tratamiento coadyuvante, el tama\u00f1o tumoral, el tipohistol\u00f3gico y el grado de diferenciaci\u00f3n. En los casos sometidos a cirug\u00eda conservadora el margen  quir\u00fargico menor de 2 mm y la presencia de componente intraductal extenso (igual o superior al 25%) se relacionan estrechamente con una mayor probabilidad de recidiva locorregional, aunque no la supervivencia global no se ve afectada.Los par\u00e1metros que influyen significativamente en la supervivencia global son: la edad, el tratamiento coadyuvante, el tama\u00f1o tumoral, el grado de diferenciaci\u00f3n, los receptores estrog\u00e9nicos y la prote\u00edna  p53. En el an\u00e1lisis multivariante demuestran su significaci\u00f3n pron\u00f3stica independiente el grado histol\u00f3gico, el tama\u00f1o tumoral y la prote\u00edna p53.  son i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos del carcinoma infiltrante de mama sin afectaci\u00f3n ganclionar axilar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos del carcinoma infiltrante de mama sin afectaci\u00f3n ganclionar axilar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Josefa Herrera De La Muela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Calero Cuerda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Escudero fernandez <\/li>\n<li> Ordas santo tom\u00e1s Juan (vocal)<\/li>\n<li>Juan  ignacio \u00e1lvarez de los heros (vocal)<\/li>\n<li>Antonio L\u00f3pez salva (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Josefa Herrera De La Muela Se realiza un estudio de los factores pron\u00f3sticos del carcinoma infiltrante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,135,347],"tags":[22861,76190,7116,179998,5027,14364],"class_list":["post-85507","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","category-oncologia-clinica","tag-antonio-lopez-salva","tag-francisco-calero-cuerda","tag-juan-ignacio-alvarez-de-los-heros","tag-m-josefa-herrera-de-la-muela","tag-manuel-escudero-fernandez","tag-ordas-santo-tomas-juan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85507"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85507\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}