{"id":85518,"date":"2018-03-10T00:09:57","date_gmt":"2018-03-10T00:09:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/radioterapia-intraoperatoria-en-cancer-no-microca%c2%adtico-pulmonar-tratado-con-quimioterapia-neoadyuvante\/"},"modified":"2018-03-10T00:09:57","modified_gmt":"2018-03-10T00:09:57","slug":"radioterapia-intraoperatoria-en-cancer-no-microca%c2%adtico-pulmonar-tratado-con-quimioterapia-neoadyuvante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/radioterapia-intraoperatoria-en-cancer-no-microca%c2%adtico-pulmonar-tratado-con-quimioterapia-neoadyuvante\/","title":{"rendered":"Radioterapia intraoperatoria en cancer no microc\u00edtico pulmonar tratado con quimioterapia neoadyuvante"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Javier Aristu Mendioroz <\/strong><\/h2>\n<p>Objetivos: estudiar la factibilidad de la radioterapia intraoperativa (rio) en c\u00e1ncer no microc\u00edtico pulmonar (cnmp) susceptible de quimioterapia neoadyuvante (qtna), cirugia (c) y radioterapia (rt) y analizar los parametros potencialmente asociados a toxicidad postoperatoria, aguda y tardia. Identificar grupos pron\u00f3stico con comportamiento diferencial en control local y supervivencia.  material y metodos: el tratamiento ha consistido en qtna con pauta mvp (mitomicina c 8 mg\/m2 dia 1, vindesina 3 mg\/m2 dias 1 y 14 y cisplatino 120 mg\/m2 dia 1) o pauta mcp (la vindesina fue sustituida por carboplatino 150 mg\/m2 intra-arterial dia 1). Los tumores quirurgicamente resecables fueron tratados posteriormente con cirugia, rio (10-15 gy) y rt posoperatoria (45 gy) y los no respondedores o irresecables recibieron rt preoperatoria.  resultados: desde 10\/84 a 12\/93, 104 pacientes con cnmp han sido incluidos en el estudio. Ventid\u00f3s pacientes no recibieron qtna, 46 pacientes recibieron rt postoperatoria y 36 pacientes(18 tumores de pancoast) fueron tratados con rt preoperatoria. La distribuci\u00f3n por estadios fue 18 iib,28 iiia y 58 iiib. La mediana de edad ha sido 60,5 a\u00f1os. Se han utilizado 130 campos de rio,4 niveles de dosis (10 gy, 12,5 gy, 15 gy y 24 gy). 7 tama\u00f1os de cono(5,6,7,8,9,10 y 12 centimetros de diametro), abordando 3 zonas intrator\u00e1cicas (mediastino, hilio, y pared tor\u00e1cica), sin accidentalidad intra-rio. La toxicidad aguda y la toxicidad desarrollada en el periodo postoperatorio han sido principalmente esofagitis (25%), neumonitis\/neumonia (14%), abasceso\/empiema (5%), fistula bronco-pleural (3%), hemorragia pulmonar (2%) y tromboembolismo pulmonar (2%). Cinco de 24 pacientes (21%) desarrollaron neuropat\u00eda braquial relacionada con dosis-rio superiores a 10 gy sobre v\u00e9rtice pulmonar (p=0,053). la aposici\u00f3n de un colgajo vascularizado sobre el mu\u00f1\u00f3n bronquial es un factor protector de complicaciones infecciosas (p=0,05). El c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Radioterapia intraoperatoria en cancer no microc\u00edtico pulmonar tratado con quimioterapia neoadyuvante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Radioterapia intraoperatoria en cancer no microc\u00edtico pulmonar tratado con quimioterapia neoadyuvante <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Javier Aristu Mendioroz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Herreros gonzalez <\/li>\n<li> Calvo Manuel felipe angel (vocal)<\/li>\n<li>ignacio Lucas ros (vocal)<\/li>\n<li> Garc\u00eda puche Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Javier Aristu Mendioroz Objetivos: estudiar la factibilidad de la radioterapia intraoperativa (rio) en c\u00e1ncer no microc\u00edtico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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