{"id":85560,"date":"2000-03-07T00:00:00","date_gmt":"2000-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-determinacion-de-enzimas-lisosomales-y-otros-marcadores-de-lesion-tubular-renal-en-la-pancreatitis-aguda\/"},"modified":"2000-03-07T00:00:00","modified_gmt":"2000-03-07T00:00:00","slug":"valor-pronostico-de-la-determinacion-de-enzimas-lisosomales-y-otros-marcadores-de-lesion-tubular-renal-en-la-pancreatitis-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-determinacion-de-enzimas-lisosomales-y-otros-marcadores-de-lesion-tubular-renal-en-la-pancreatitis-aguda\/","title":{"rendered":"Valor pron\u00f3stico de la determinaci\u00f3n de enzimas lisosomales y otros marcadores de lesi\u00f3n tubular renal en la pancreatitis aguda."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agust\u00edn Gutierrez Casado <\/strong><\/h2>\n<p>Las enzimas liosomales, implicadas en la fisopatolog\u00eda de la pancreatitis aguda (pa) seg\u00fan algunas teor\u00edas, podr\u00edan liberarse del p\u00e1ncreas y mostrar una actividad elevada en suero. Por otra parte, la pa da lugar a una alteraci\u00f3n del t\u00fabulo renal, que cursa con excreci\u00f3n aumentada en orina de prote\u00ednas y enzimas lisosomales renales. La lesi\u00f3n del t\u00fabulo es inducida por la llegada al ri\u00f1\u00f3n de grandes cantidades de prote\u00ednas, normales o patol\u00f3gicas, liberdas por el p\u00e1ncreas. El grado de lesi\u00f3n tubular puede relacionarse con la extensi\u00f3n local de la pa y tener valor pron\u00f3stico.  objetivo  estudiar el valor pron\u00f3stico, en la pa, de la determinaci\u00f3n de las enzimas lisosomales en suero, y de los marcadores de lesi\u00f3n tubular renal prote\u00edna, a1-microglobulina (prote\u00edna de bajo peso molecular), n-acetil-glucosaminidasa (nag) y b-glucuronidasa, en orina, estos dos \u00faltimos enzimas lisosomales de origen renal.  pacientes y m\u00e9todos  se estudiaron 63 pacientes con pa (47leves y 16graves, seg\u00fan los criterios de atlanta). Se determin\u00f3, al ingreso y durante los 5 primeros d\u00edas de evoluci\u00f3n, en suero, la actividad de las enzimas lisosomales nag, b-glucuronidasa y fosfatasa \u00e1cidada, y los niveles de prote\u00edna c reactiva y, en orina, los niveles de los marcadores de lesi\u00f3n tubular renal nag-b-glucuronidasa, prote\u00edna y a1-microglobulina. Tambi\u00e9n se recogieron los datos para completar los criterios e ranson y el apache ii. El valor pron\u00f3stico de cada marcador se obtuvo determinando el \u00edndice predictivo de gravedad, de cada uno de ellos, mediante el m\u00e9todo roc.  resultados  en suero, s\u00f3lo se observaron peque\u00f1as variaciones de la actividad de las enzimas lisosomales nag y b-glucuronidasa, que no se relacionaron con la liberaci\u00f3n de enzimas pancre\u00e1ticas digestibas. Enorina, los niveles de los marcadores de lesi\u00f3n tubular renal mostraron, en los pacientes con pa, aumentos muy importantes,precoces y significativos, qu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la determinaci\u00f3n de enzimas lisosomales y otros marcadores de lesi\u00f3n tubular renal en la pancreatitis aguda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la determinaci\u00f3n de enzimas lisosomales y otros marcadores de lesi\u00f3n tubular renal en la pancreatitis aguda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agust\u00edn Gutierrez Casado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Rius Cornado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Armengol carrasco <\/li>\n<li>eduard Jaurrieta mas (vocal)<\/li>\n<li>francesc Gonz\u00e1lez sastre (vocal)<\/li>\n<li>Luisa Guarner aguilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agust\u00edn Gutierrez Casado Las enzimas liosomales, implicadas en la fisopatolog\u00eda de la pancreatitis aguda (pa) seg\u00fan algunas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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