{"id":85590,"date":"2000-04-07T00:00:00","date_gmt":"2000-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-hipermetilacion-de-p16-en-cancer-de-pulmon-no-microcitico\/"},"modified":"2000-04-07T00:00:00","modified_gmt":"2000-04-07T00:00:00","slug":"valor-pronostico-de-la-hipermetilacion-de-p16-en-cancer-de-pulmon-no-microcitico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/valor-pronostico-de-la-hipermetilacion-de-p16-en-cancer-de-pulmon-no-microcitico\/","title":{"rendered":"Valor pronostico de la hipermetilacion de p16 en cancer de pulmon no microcitico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Godino Garcia <\/strong><\/h2>\n<p>El gen p16 (ink4a-mts-1,cdkn22) se encuentra localizado en el cromosoma 9p21, un sitio de frecuentes p\u00e9rdidas al\u00e9licas en muchos tumores humanos. codifica una prote\u00edna de 15,8 kd de peso molecular llamada p16, la cual bloquea la progresi\u00f3nd el cilo celular de la fase g1 a la fase s por uni\u00f3n conkinasas dependientes de ciclinas (cdk4 y cdk6, respectivamente), inhibiendo la acci\u00f3nfosforilante de la ciclina d1 sobre la prote\u00edna del retinobastoma.  mediante un nuevo m\u00e9todo llamado msp (meethlation-specific pcr) se estudia el estado de melitaci\u00f3n del gen p16 en 44 carcinomas de pulm\u00f3n no microc\u00edticos (cpnm). Tambi\u00e9n se estudia la loh y la inestabilidad de microsat\u00e9lites en la regi\u00f3n 9p21 de p16 mediante pcr en 98cpnm.  se relacionan los resultados obtenidos con las variables cl\u00ednico-patol\u00f3gicas y los factores pron\u00f3stico cl\u00e1sicos.  se estudia el valor pron\u00f3stico de las alteraciones gen\u00e9ticas estudiadas en cuanto a la supervivencia global y a la superviviencia libre de enfermedad de los pacientes con cpnm.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico de la hipermetilacion de p16 en cancer de pulmon no microcitico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico de la hipermetilacion de p16 en cancer de pulmon no microcitico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Godino Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Maestro De Las Casas M. Luisa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  cantero <\/li>\n<li>Luis Izquierdo l\u00f3pez (vocal)<\/li>\n<li>Antonio Ballesta gimeno (vocal)<\/li>\n<li>encarnacion Adrover cebrian (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Godino Garcia El gen p16 (ink4a-mts-1,cdkn22) se encuentra localizado en el cromosoma 9p21, un sitio de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[180134,19865,92312,4963,180135,55109],"class_list":["post-85590","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-ana-godino-garcia","tag-antonio-ballesta-gimeno","tag-encarnacion-adrover-cebrian","tag-jose-luis-balibrea-cantero","tag-luis-izquierdo-lopez","tag-maestro-de-las-casas-m-luisa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85590"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85590\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85590"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85590"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}