{"id":85616,"date":"2000-04-07T00:00:00","date_gmt":"2000-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-un-programa-de-quimio-radioterapia-preoperatoria-y-cirugia-en-el-tratamiento-del-cancer-de-recto\/"},"modified":"2000-04-07T00:00:00","modified_gmt":"2000-04-07T00:00:00","slug":"analisis-de-un-programa-de-quimio-radioterapia-preoperatoria-y-cirugia-en-el-tratamiento-del-cancer-de-recto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-de-un-programa-de-quimio-radioterapia-preoperatoria-y-cirugia-en-el-tratamiento-del-cancer-de-recto\/","title":{"rendered":"Analisis de un programa de quimio-radioterapia preoperatoria y cirugia en el tratamiento del cancer de recto"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Baixauli Fons <\/strong><\/h2>\n<p>Introducci\u00f3n  las terapias complementarias (quimio-radioterapia) a la cirugia, aplicadas en el tratamiento del cancer de recto, deben ayudar a la consecuci\u00f3n de unos buenos resultados, no s\u00f3lo en terminos de supervivencia, sino tambien disminuyendo las tasas de recidiva local y preservando una buena calidad de vida del paciente, sobre todo con el mantenimiento de la funci\u00f3n de continencia fecal y genitourinaria.  material y m\u00e9todos  se estudian retrospectivamente 283 pacientes intervenidos de cancer de recto en nuestro centro entre 1985 y 1999 dividi\u00e9ndolos en dos grupos en funci\u00f3n de la administraci\u00f3n de quimio-radioterapia preoperatoria (n=159) o no (n=124). Se efectua un analisis multivariante de la supervivencia global y libre de enfermedad, aplicando un modelo de regresi\u00f3n de cox, asi como de la morbilidad, mediante modelos de regresi\u00f3n log\u00edstica m\u00faltiple.  resultados:  la aplicaci\u00f3n de quimio-radioterapia preoperatoria se asoci\u00f3 a un porcentaje significativamente superior de preservaci\u00f3n de la funci\u00f3n esfinteriana, si bien implic\u00f3 un incremento significativo, en el an\u00e1lisis multivariante, del riesgo de padecer diarrea (odds ratio, or:5,18) tenesmo (or: 3,80), incontinencia fecal (or: 16,58), y disfunci\u00f3n sexual (or: 3,20). En el analisis multivariante la administraci\u00f3n del tratamiento neoadyuvante se asoci\u00f3 a un retraso en la aparici\u00f3n de recidiva tumoral (hazard ratio, hr: 0,90) y una mejoria en la supervivencia global (hr:0,88), aunque las diferencias halladas no alcanzaron significaci\u00f3n estadistica.  la radioterapia (rio) supuso un incremento significativo, en el analisis multivariante, del riesgo de padecer dehiscencia anastom\u00f3tica (or: 5,5), y absceso pelvico-abdominal (or:4,88); sin embargo retras\u00f3 de forma significativa la aparici\u00f3n de recidiva tumoral (hr:0,45), no influyendo en la supervivencia global.  conclusiones:  en nuestro estudio se aprecia un efecto protector frente a la aparici\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de un programa de quimio-radioterapia preoperatoria y cirugia en el tratamiento del cancer de recto<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de un programa de quimio-radioterapia preoperatoria y cirugia en el tratamiento del cancer de recto <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Baixauli Fons <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Hern\u00e1ndez Lizo\u00e1in<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Pardo mind\u00e1n <\/li>\n<li>Juan  Javier Zudaire bergera (vocal)<\/li>\n<li>damian Garc\u00eda olmo (vocal)<\/li>\n<li> Martinez gonzalez Miguel angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Baixauli Fons Introducci\u00f3n las terapias complementarias (quimio-radioterapia) a la cirugia, aplicadas en el tratamiento del cancer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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