{"id":85632,"date":"2000-05-07T00:00:00","date_gmt":"2000-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-adenosina-y-los-opioides-como-reguladores-de-la-actividad-neuronal-del-plexo-mienterico\/"},"modified":"2000-05-07T00:00:00","modified_gmt":"2000-05-07T00:00:00","slug":"la-adenosina-y-los-opioides-como-reguladores-de-la-actividad-neuronal-del-plexo-mienterico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-adenosina-y-los-opioides-como-reguladores-de-la-actividad-neuronal-del-plexo-mienterico\/","title":{"rendered":"La adenosina y los opioides como reguladores de la actividad neuronal del plexo mient\u00e9rico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Abalo Delgado <\/strong><\/h2>\n<p>El plexo mient\u00e9rico es el encargo de controlar las funciones motoras del tracto gastrointestinal de los mam\u00edferos y este control lo ejerce de forma pr\u00e1cticamente independiente del control central. En el presente trabajo se han utilizado diferentes preparaciones de \u00edleon de cobayo, combinando t\u00e9cnicas farmacol\u00f3gicas tradicionales con t\u00e9cnicas electrofisiol\u00f3gicas, para estudiar:  -la influencia de la adenosina en la peristalsis. Se han realizado estudios de la actividad contr\u00e1ctil de las capas de musculatura longitudinal y circular, as\u00ed como de la actividad el\u00e9ctrica de las neuronas mient\u00e9ricas y de las c\u00e9lulas musculares circulares. Nuestros resultados demuestran que la adenosina, al menos a trav\u00e9s de receptores a1, act\u00faa como modulador de la peristalsis, mediante mecanismos que implican tanto circuitos excitadores como inhibidores.  -la implicaci\u00f3n de las prote\u00ednas gi\/o en el efecto de los agonistas opioides mu y kappa sobre la transmisi\u00f3n sin\u00e1ptica neuronal, as\u00ed como su posible correlaci\u00f3n con efectos opioides en ensayos de contractilidad del m\u00fasculo longitudinal. Nuestros resultados demuestran que la acci\u00f3n opioide sobre la contractilidad muscular est\u00e1 relacionada con una inhibici\u00f3n de la transmisi\u00f3n sin\u00e1ptica r\u00e1pida y que ambas acciones est\u00e1n mediadas por prote\u00ednas gi\/o sensibles a toxina pertusis.  las conclusiones generales de la presente tesis doctoral son las siguientes:  1- la adenosina y los opioides son capaces de modular la actividad el\u00e9ctrica de las neuronas del plexo mient\u00e9rico de \u00edleon de cobayo.  2- dicha modulaci\u00f3n puede explicar, al menos parcialmente, las modificaciones de la motilidad y la actividad contr\u00e1ctil de las capas musculares del \u00edleon de cobayo.  3-el estudio de la actividad el\u00e9ctrica de las neuronas mient\u00e9ricas es \u00fatil para lograr una aproximaci\u00f3n m\u00e1s \u00edntima a los mecanismos de acci\u00f3n celulares y tisulares de sustancias como la adenosina y los opioides.  4- la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La adenosina y los opioides como reguladores de la actividad neuronal del plexo mient\u00e9rico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La adenosina y los opioides como reguladores de la actividad neuronal del plexo mient\u00e9rico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Abalo Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel Martin Fontelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo men\u00e9ndez <\/li>\n<li>M\u00aaisabel Colado megia (vocal)<\/li>\n<li>Mar\u00eda victoria Milan\u00e9s maquil\u00f3n (vocal)<\/li>\n<li>eduardo Garcia poblete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Abalo Delgado El plexo mient\u00e9rico es el encargo de controlar las funciones motoras del tracto gastrointestinal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957],"tags":[20539,4665,6039,8481,180197,146724],"class_list":["post-85632","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","tag-eduardo-garcia-poblete","tag-juan-luis-tamargo-menendez","tag-maria-isabel-martin-fontelles","tag-maria-victoria-milanes-maquilon","tag-maisabel-colado-megia","tag-raquel-abalo-delgado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85632"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85632\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}