{"id":85663,"date":"2000-06-07T00:00:00","date_gmt":"2000-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-vitamina-e-y-melatonina-en-estres-oxidativo-en-la-ictericia-obstructiva-experimental\/"},"modified":"2000-06-07T00:00:00","modified_gmt":"2000-06-07T00:00:00","slug":"efectos-de-la-vitamina-e-y-melatonina-en-estres-oxidativo-en-la-ictericia-obstructiva-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-vitamina-e-y-melatonina-en-estres-oxidativo-en-la-ictericia-obstructiva-experimental\/","title":{"rendered":"Efectos de la vitamina e y melatonina en estres oxidativo en la ictericia obstructiva experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adolfo Cruz Mu\u00f1oz <\/strong><\/h2>\n<p>Objetivos:el objetivo del presente estudio fue en primer lugar compara los efectos de la vitamina e y melatonina sobre los marcadores de estr\u00e9s oxidativo (lipoper\u00f3sidos, medidos como malonildialdeh\u00eddo (mda), glutati\u00f3n reducido (gsh) y glutaci\u00f3n oxidado (gssg) y sobre las alteraciones bioqu\u00edmicas asociadas a la ictericia obstructiva experimental (biblittubina, fa, ggt, alt y ast); en segundo lugar, evaluar la actividad de las enzimas antioxidantes tras la adminsitraci\u00f3n de los antioxidantes (cartalasa, super\u00f3xido dismutasa (sod),glutaci\u00f3n reductasa (gsh-rd), glutaci\u00f3n peroxidasa (gsh-px) y glutaci\u00f3n transferasa (gsh-tr).  metodo:la colestasis experimental fue conseguida en ratas wistar macho mediante doble ligadura y secci\u00f1on de la v\u00eda biliar principal que fue mantenida durante 7 d\u00edas. Tanto la vitamina  e (15 mg\/kg\/48h ip) como la malatonina (500 microg\/kg\/24h ip) fueron administradas desde un d\u00eda antes de su intervenci\u00f3n hasta el d\u00eda de su sacrificio.  resultados:la ligadura de la v\u00eda biliar se acompa\u00f1\u00f3 de un significativo incrememto de las cifras de mda y de gssg as\u00ed como de un significativo descenso tanto en los valores de gsh como en la actividad de las enzimas antioxidantes excepto para la gsh-px.La administraci\u00f3n de antioxidantes determinaron un significativo descenso en las cifras de mda as\u00ed como una elevaci\u00f3n significativa del gsh, aunque el efecto de la melatonina fue superior en relaci\u00f3n a la vitamina e. La actividad de las enzimas antioxidantes experimentaron un significativo incremeneo bajo la acci\u00f3n de la melatonina; por el contrario, la vitamina e apenas tuvo efecto sobre la actividad de dichos enzimas. Los antioxidantes disminuyeron significativamente las cifras de bilirrubinas, aunque s\u00f3lo la melatonina descendi\u00f3 las cifras de alt y ast.  conclusiones: en nuestro estudio la melatonina ha sido m\u00e1s eficaz que la vitamina e en reducir los par\u00e1metros de colestasis y el grado de estr\u00e9s oxidativ<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la vitamina e y melatonina en estres oxidativo en la ictericia obstructiva experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la vitamina e y melatonina en estres oxidativo en la ictericia obstructiva experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adolfo Cruz Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Montilla Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Pera madrazo <\/li>\n<li> Sanchez de la cuesta felipe (vocal)<\/li>\n<li>gonzalo Mi\u00f1o fugarolas (vocal)<\/li>\n<li> Guerrero montavez Juan  Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adolfo Cruz Mu\u00f1oz Objetivos:el objetivo del presente estudio fue en primer lugar compara los efectos de la 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