{"id":85689,"date":"2000-06-07T00:00:00","date_gmt":"2000-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/osteostatina-un-nuevo-factor-en-la-regulacion-de-la-celula-osteoformadora\/"},"modified":"2000-06-07T00:00:00","modified_gmt":"2000-06-07T00:00:00","slug":"osteostatina-un-nuevo-factor-en-la-regulacion-de-la-celula-osteoformadora","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/osteostatina-un-nuevo-factor-en-la-regulacion-de-la-celula-osteoformadora\/","title":{"rendered":"Osteostatina: un nuevo factor en la regulacion de la celula osteoformadora."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alvaro Valin Garcia <\/strong><\/h2>\n<p>La prote\u00edna relacionada con la parathormona (pthrp) es un factor producido por los osteoblastos, con acciones similares a las de la pth sobre el remodelado \u00f3seo, al menos en los efectos mediados a trav\u00e9s de su regi\u00f3n n-terminal. por otra parte, la regi\u00f3n c-terminal de la pthrp no hom\u00f3loga con la pthrp no hom\u00f3loga con la pth, que contiene el ep\u00edtopo 107-111 (osteostatina), es un potente inhibidor de la resorci\u00f3n \u00f3sea. En el presente trabajo, hemos investigado los efectos del posible fragmento de la pthrp(107-139), que contiene la osteostatina, sobre la funci\u00f3n  osteobl\u00e1stica en c\u00e9l. De osteosarcoma de rata de fenotipo osteobl\u00e1stico umr106 y en c\u00e9l. Osteobl\u00e1sticas de hueso trabecular humano (hob), con diferente grado de diferenciaci\u00f3n. Nuestros estudios demuestran que tanto la pthrp(107-111) como la pthrp(107-139) son antiproliferativas e inhiben la actividad fosfatasa alcalina, un marcador de diferenciaci\u00f3n osteobl\u00e1stica, en ambos tipos. Estos efectos parecen venir mediados a trav\u00e9s de la estimulaci\u00f3n de la v\u00eda prote\u00edna quinasa c y no por la prote\u00edna quinasa a. Adem\u00e1s este fragmento de la pthrp es capaz de estimular la movilizaci\u00f3n de cai2+ a trav\u00e9s de canales de calcio dependientes de voltaje. El fragmento c-i terminal de la pthrp es capaz de modular la activaci\u00f3n de la se\u00f1al de cai2+, as\u00ed como la de la pka, generada por pthrp n-terminal. La expresi\u00f3n del protooncogen c-fos, implicado en los procesos de diferenciaci\u00f3n osteobl\u00e1stica, fue estimulada por la pthrp(107-139) de un modo r\u00e1pido y transitorio. As\u00ed mismo, la actividad del factor de transcripci\u00f3n ap-1, del cual forma parte el c-fos, tambi\u00e9n fue estimulada tras la adici\u00f3n de la pthrp c-terminal en c\u00e9lulas umr 106.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Osteostatina: un nuevo factor en la regulacion de la celula osteoformadora.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Osteostatina: un nuevo factor en la regulacion de la celula osteoformadora. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alvaro Valin Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Esbrit Arguelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Munuera Martinez <\/li>\n<li>gabriel Herrero-beaumont cuenca (vocal)<\/li>\n<li> Martinez gomez Mar\u00eda  eugenia (vocal)<\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvaro Valin Garcia La prote\u00edna relacionada con la parathormona (pthrp) es un factor producido por los osteoblastos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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