{"id":85719,"date":"2000-07-07T00:00:00","date_gmt":"2000-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-inmunogeneticos-de-susceptibilidad-en-la-enfermedad-de-chagas\/"},"modified":"2000-07-07T00:00:00","modified_gmt":"2000-07-07T00:00:00","slug":"factores-inmunogeneticos-de-susceptibilidad-en-la-enfermedad-de-chagas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/factores-inmunogeneticos-de-susceptibilidad-en-la-enfermedad-de-chagas\/","title":{"rendered":"Factores inmunogen\u00e9ticos de susceptibilidad en la enfermedad de chagas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Calzada Lombana Jos\u00e9 Eduardo <\/strong><\/h2>\n<p>En la presente investigaci\u00f3n se analiza la posible influencia de los genes: hla de clase i, nos2, ccr5, tgfb1 y nramp1, sobre la susceptibilidad a la infecci\u00f3n por trypanosoma cruzi y bre el desarrollo de formas severas de esta efnfermedad. Con este fin se estudiaron 156 sujetos no relacionados pertenecientes a una regi\u00f3n rural del sur de per\u00fa, considerada end\u00e9mica para la enfermedad de chagas. Seg\u00fan los resultados de tres pruebas serol\u00f3gicas la poblaci\u00f3n de estudio se dividi\u00f3 en controles seronegativos y pacientes seropositivos. El grupo de serpositivos se subdividi\u00f3 en asintom\u00e1ticos y cardiacos basados en los resultados de ex\u00e1menes cl\u00ednicos y electrocardiogramas. las frecuencias de los polomorfismos gen\u00e9ticos fueron comparadas en estos distintos grupos.  al analizar los genes hla de clase i se observ\u00f3 que el haplotipo b*15-cw*01 ejerc\u00eda un efecto protector dominante en la infecci\u00f3n por t. Cruzi, mientras que el haplotipo extendido a*02-b+3505-cw*04 confer\u00eda una mayor susceptibilidad a la infecci\u00f3n. Los polimorfismos estudiados de los genes nos2, tgfb1 y nramp1 no se encontraron asociados de forma significativa conla susceptibilidad a la infecci\u00f3n o con la predisposici\u00f3n a padecer cardiomiopat\u00eda chag\u00e1sica en la poblaci\u00f3n evaluada.  por otra parte el genotipo a\/g del polomorfismo 59029 del gene ccr5 parece ejercer un efecto protector sobre el desarrollo de cardiomiopat\u00eda chag\u00e1sica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores inmunogen\u00e9ticos de susceptibilidad en la enfermedad de chagas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores inmunogen\u00e9ticos de susceptibilidad en la enfermedad de chagas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Calzada Lombana Jos\u00e9 Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Martin Iba\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Garcia olivares <\/li>\n<li>Miguel angel L\u00f3pez nevot (vocal)<\/li>\n<li>Antonio Alcina madue\u00f1o (vocal)<\/li>\n<li> Gaforio Martinez Juan  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Calzada Lombana Jos\u00e9 Eduardo En la presente investigaci\u00f3n se analiza la posible influencia de los genes: hla [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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