{"id":85733,"date":"2000-07-07T00:00:00","date_gmt":"2000-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-administracion-de-beta-ciclodextrina-en-la-dieta-sobre-el-perfil-lipa%c2%addico-de-ratas-hipercolesterolemicas\/"},"modified":"2000-07-07T00:00:00","modified_gmt":"2000-07-07T00:00:00","slug":"efecto-de-la-administracion-de-beta-ciclodextrina-en-la-dieta-sobre-el-perfil-lipa%c2%addico-de-ratas-hipercolesterolemicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-de-la-administracion-de-beta-ciclodextrina-en-la-dieta-sobre-el-perfil-lipa%c2%addico-de-ratas-hipercolesterolemicas\/","title":{"rendered":"\u00abefecto de la administraci\u00f3n de beta-ciclodextrina en la dieta sobre el perfil lip\u00eddico de ratas hipercolesterol\u00e9micas\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Villares Garcia <\/strong><\/h2>\n<p>La identificaci\u00f3n y caracterizaci\u00f3n de sustancias naturales con actividad hipocolesteremiante tienen gran revelancia en nuestra sociedad en la que se detecta una persistente progresi\u00f3n de hipercolesterolemia.  las b-ciclodextrinas, son oligosac\u00e1ridos c\u00edclicos solubles en agua y con una cavidad hidrof\u00f3bica capaz de albergar compuestos hidrof\u00f3bicos y vehiculizados en soluciones acuosas.  el objetivo del presente estudio fue cuantificar la posible acci\u00f3n hipolesterol\u00e9mica de la administraci\u00f3n de distintas dosis de b-ciclodextrina-reducci\u00f3n que la acumulaci\u00f3n hep\u00e1tica y s\u00e9rica de colesterol-, y explicar, en su caso, los mecanismos bioqu\u00edmicos de este efecto.  las conclusiones fueron:1-la dieta que contiene el oligosac\u00e1rico c\u00edclico indujo un decrecimiento de los niveles de fosfol\u00edpidos y triglic\u00e9ridos plasm\u00e1ticos acompa\u00f1ado de menores niveles de vldl. 2- se produjo una disminuci\u00f3n de la relaci\u00f3n colesterol libre\/esterificado en h\u00edgado. 3- la dieta hipercolesterol\u00e9mica caus\u00f3 un decrecimiento en la s\u00edntesis hep\u00e1tica de colesterol, marcada por una actividad de la enzima hmg-coa reductasa hep\u00e1tica, que no fue revertido por la acci\u00f3n de b-ciclodextrina. 4.-La b-ciclodextrina indujo incremento de la v\u00eda catab\u00f3lica, medida por la actividad 7   -hidroxilasa hep\u00e1tica de modo dosis dependiente. 5.-Las dietas ricas en ciclodextrina producen una disminuci\u00f3n de la recirculaci\u00f3n hep\u00e1tica de \u00e1cidos biliares mediante el arrastre a heces unido al oligosac\u00e1rido no hidrolizado. Los \u00e1cidos biliares parecen afectar directamente a la 7  -hidroxilasa, m\u00e1s que mediante la supresi\u00f3n primaria de la hmg-coa reductosa, sin que se pueda descartar la inducci\u00f3n de otras v\u00edas catab\u00f3licas a \u00e1cidos biliares como las 27 hidroxilasa mitocondrial. 6.- Finalmente la b- ciclodextrina indujo aumento significativo de las transaminasa hep\u00e1ticas de un modo dosis dependiente. Igualmente, los estudios histol\u00f3gicos mostraron signos evidentes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abefecto de la administraci\u00f3n de beta-ciclodextrina en la dieta sobre el perfil lip\u00eddico de ratas hipercolesterol\u00e9micas\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abefecto de la administraci\u00f3n de beta-ciclodextrina en la dieta sobre el perfil lip\u00eddico de ratas hipercolesterol\u00e9micas\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Villares Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bayon Darkistade Jos\u00e9 Enrique<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Jimenez fern\u00e1ndez <\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja suarez (vocal)<\/li>\n<li>abelardo Garc\u00eda de lorenzo (vocal)<\/li>\n<li>Francisco Jorquera plaza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Villares Garcia La identificaci\u00f3n y caracterizaci\u00f3n de sustancias naturales con actividad hipocolesteremiante tienen gran revelancia en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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