{"id":85760,"date":"2000-07-07T00:00:00","date_gmt":"2000-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-la-expresion-del-factor-de-transcripcion-homeotico-ttf-1-y-su-regulacion-por-glucocorticoides-en-el-modelo-experimental-de-hipoplasia-pulmonar\/"},"modified":"2000-07-07T00:00:00","modified_gmt":"2000-07-07T00:00:00","slug":"inhibicion-de-la-expresion-del-factor-de-transcripcion-homeotico-ttf-1-y-su-regulacion-por-glucocorticoides-en-el-modelo-experimental-de-hipoplasia-pulmonar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/inhibicion-de-la-expresion-del-factor-de-transcripcion-homeotico-ttf-1-y-su-regulacion-por-glucocorticoides-en-el-modelo-experimental-de-hipoplasia-pulmonar\/","title":{"rendered":"Inhibicion de la expresion del factor de transcripci\u00f3n homeotico ttf-1 y su regulacion por glucocorticoides en el modelo experimental de hipoplasia pulmonar."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Losada Gonzalez <\/strong><\/h2>\n<p>El factor de transcripci\u00f3n ttf-1 tiene un papel esencial en la morfog\u00e9nesis y desarrollo pulmonar. Adem\u00e1s regula la expresi\u00f3n de las prote\u00ednas del surfactante, las cuales  son imprescindibles para la funci\u00f3n respiratoria. los neonatos que presentan una hernia daiafragm\u00e1tica cong\u00e9nita mueren por un fallo respiratorio como consecuencia de la hipoplasia pulmonar y la inmadurez bioqu\u00edmica asociada. Para profundizar en las causas de esta enfermedad y en el efecto de la terapia hormonal utilizada para el tratamiento de estos pacientes, hemos estudiado el factor de trasncripci\u00f3n ttf-1 como marcador de la morfog\u00e9nesis pulmonar yla prote\u00edna sp-b como marcador de la maduraci\u00f3n pulmonar.  usando un modelo de hipoplasia pulmonar en rata, hemos demostrado que los niveles de rnam de ttf-1 y sp-b est\u00e1ndisminuidos en los pulmonares hipopl\u00e1sicos. El tratamiento con dexametasona aumenta los niveles de ambos rnam por encima de los valores de los controles cuando se tratan animales con los pulmones hipopl\u00e1sicos,pero sin embargo no tiene ning\u00fan efecto cuando se adminsitra a animales controles.  thr tambi\u00e9n aumenta los niveles del rnam de ttf-1 y sp-b, pero en menor media que los glucocorticoides. Cuando se administran juntos, trh inhibe parcialmente los efectos de la dexametasona. La disminuci\u00f3n en los niveles del rnam de ttf-1 se correlacionan con una disminuci\u00f3n en los niveles de prote\u00edna y enla capacidad de \u00e9sta de unirse al dna cuando se utiliza como sonda un oligonucle\u00f3tido con el sitio de uni\u00f3n para ttf-1 del promotor de sp-b.  todos los par\u00e1metros se restablecen despu\u00e9s del tratamiento condexametasona. adem\u00e1s,la regulaci\u00f3n en la expresi\u00f3n de ttf-1 descrita anteriormente se acompa\u00f1a con la regulaci\u00f3n de la actividad de su promotor, como se demuestra en los experimentos de transfecci\u00f3n transitoria con la l\u00ednea celular humana h441. Hemos demostrado invitro que el nitrofen disminuye la capacidad de uni\u00f3n de ttf-1 al dna<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibicion de la expresion del factor de transcripci\u00f3n homeotico ttf-1 y su regulacion por glucocorticoides en el modelo experimental de hipoplasia pulmonar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibicion de la expresion del factor de transcripci\u00f3n homeotico ttf-1 y su regulacion por glucocorticoides en el modelo experimental de hipoplasia pulmonar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Losada Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Tovar Carrucea Juan  Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Quero jim\u00e9nez <\/li>\n<li>raquel Barrio castellanos (vocal)<\/li>\n<li>Ana Aranda iriarte (vocal)<\/li>\n<li>Luis Casta\u00f1o gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Losada Gonzalez El factor de transcripci\u00f3n ttf-1 tiene un papel esencial en la morfog\u00e9nesis y desarrollo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[180396,7262,7519,117478,17551,180397],"class_list":["post-85760","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alejandro-losada-gonzalez","tag-ana-aranda-iriarte","tag-jose-quero-jimenez","tag-luis-castano-gonzalez","tag-raquel-barrio-castellanos","tag-tovar-carrucea-juan-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85760"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85760\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}