{"id":85769,"date":"2000-07-07T00:00:00","date_gmt":"2000-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-raton-deficiente-en-apolipoprotea%c2%adna-e-en-el-estudio-de-la-prevencion-y-tratamiento-de-la-arteriosclerosis\/"},"modified":"2000-07-07T00:00:00","modified_gmt":"2000-07-07T00:00:00","slug":"el-raton-deficiente-en-apolipoprotea%c2%adna-e-en-el-estudio-de-la-prevencion-y-tratamiento-de-la-arteriosclerosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-raton-deficiente-en-apolipoprotea%c2%adna-e-en-el-estudio-de-la-prevencion-y-tratamiento-de-la-arteriosclerosis\/","title":{"rendered":"El rat\u00f3n deficiente en apolipoprote\u00edna e en el estudio de la prevenci\u00f3n y tratamiento de la arteriosclerosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Paul Florit <\/strong><\/h2>\n<p>Introducci\u00f3n  la arterisoclerosis es la causante de numerosas patolog\u00edas cardiovasculares que en un conjunto constituyen la principal causa de morbi-mortabilidad en los pa\u00edses desarrollados. Los factores de riesgo aterog\u00e9nico hasta ahora concoidos no contribuyen a explicar un elevado porcentaje de las enfermedades cardiovasculares, por lo que es conveniente insisitr en la b\u00fasqueda de nuevos factores de riesgo. Dado que la evoluci\u00f3n de la arteriosclerosis en el hombre se poduce cr\u00f3nicamente a lo largo de su vida, el estudio de estos factores de riesgo en el humano tan s\u00f3lo puede llevarse a cabo mediante estudios epidemiol\u00f3gicos de larga duraci\u00f3n, lo que hace necesario para la b\u00fasqueda de nuevos factores de riesgo aterog\u00e9nico la utilizaci\u00f3n de modelos animales de arteriosclerosis.  objetivos  en el presente trabajo se pretende estudiar la contribuci\u00f3n de la hemorreolog\u00eda, modificandola mediante la producci\u00f3n de anemia, el efecto de la suplementaci\u00f3n diet\u00e9tica con los antioxidantes vitamina e y zinc y el tratamiento con dosis antiinflamatorias de \u00e1cido acetilsalic\u00edlico (aas) en el desarrollo de la arteriosclerosis en el rat\u00f3n deficiente en apolipoprote\u00edna e, un modelo animal de arteriosclerosis inducida por la elevaci\u00f3n de su colesterol plasm\u00e1tico.  resultados  la producci\u00f3n de anemia por dos mecanismos distintos (hem\u00f3lisis y sangr\u00edas) dio como resultado una disminuci\u00f3n de la viscosidad sangu\u00ednea y disminuy\u00f3 significativamente el desarrollo de arteriosclerosis en este modelo animal. el tratamiento con dosis antiinflamatorias de aas tambi\u00e9n result\u00f3 ser ateroprotector.Sin embargo, la suplementaci\u00f3n con antioxidantes no disminuy\u00f3 el desarrollo de la arteriosclerosis en estos animales.  conclusiones  1,- el hematocrito es un importante determinante de la viscosidad sangu\u00ednea en el rat\u00f3n deficiente en apolipoprote\u00edna e.  2,- la producci\u00f3n de anemia disminuye significativamente el desarrollo de arte<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El rat\u00f3n deficiente en apolipoprote\u00edna e en el estudio de la prevenci\u00f3n y tratamiento de la arteriosclerosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El rat\u00f3n deficiente en apolipoprote\u00edna e en el estudio de la prevenci\u00f3n y tratamiento de la arteriosclerosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Paul Florit <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Joven Maried<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas De la osada Garc\u00eda <\/li>\n<li>Emilio Mayayo artal (vocal)<\/li>\n<li>Jorge Camps andreu (vocal)<\/li>\n<li>lucia Calleja rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Paul Florit Introducci\u00f3n la arterisoclerosis es la causante de numerosas patolog\u00edas cardiovasculares que en un conjunto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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