{"id":85779,"date":"2000-08-07T00:00:00","date_gmt":"2000-08-07T00:00:00","guid":{"rendered":""},"modified":"2000-08-07T00:00:00","modified_gmt":"2000-08-07T00:00:00","slug":"hipercolanemia-gestacional-estudio-epidemiologico-en-la-region-de-salamanca-durante-1996-1999-y-analisis-del-efecto-sobre-la-transferencia-placentaria-de-acidos-biliares-en-modelos-experimentales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hipercolanemia-gestacional-estudio-epidemiologico-en-la-region-de-salamanca-durante-1996-1999-y-analisis-del-efecto-sobre-la-transferencia-placentaria-de-acidos-biliares-en-modelos-experimentales\/","title":{"rendered":"Hipercolanemia gestacional. estudio epidemiol\u00f3gico en la regi\u00f3n de salamanca durante 1996-1999 y an\u00e1lisis del efecto sobre la transferencia placentaria de \u00e1cidos biliares en modelos experimentales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jes\u00fas Pascual Vallejo <\/strong><\/h2>\n<p>Introducci\u00f3n:la colestasis intrahep\u00e1tica gestacional(cig) es una enfermedad poco frecuente en nuestro pa\u00eds, aunque su preValencia es elevada en portugal. la cig va acompa\u00f1ada de hipercolanemia, que puede ser causante de cambios en la funci\u00f3n de transporte de \u00e1cidos biliares a trav\u00e9s de la placenta. objetivos:evaluar la incidencia de la hipercolanemia gestacional subcl\u00ednica en el \u00e1rea de salamanca y caracterizar el efecto de esta sobre la funci\u00f3n de la plancenta de transferencia feto-materna de \u00e1cidos biliares. Determinar si la terapia con \u00e1cido ursodesoxic\u00f3lico(audc) revierte los efectos nocivos de los \u00e1cidos biliares sobre la placenta. Investigar si la uni\u00f3n del cisplatino a un acido biliar disminuye la transferencia placentaria retr\u00f3grada madre-feto y reduce la exposici\u00f3n del feto a esta droga. M\u00e9todos: an\u00e1lisis de concentraci\u00f3n de \u00e1cidos biliares por fluorescencia y por cromatografia de gases acoplada a espectometr\u00eda de masas y determinaci\u00f3n de par\u00e1metros bioqu\u00edmicos del perfil hep\u00e1tico en gestantes sanas del \u00e1rea de salamanca y en gestantes control, gestantes diagnosticadas con cig y gestantes con cig tratadas con audc. An\u00e1lisis del transporte de \u00e1cidos biliares a trav\u00e9s de las membranas plasm\u00e1ticas de trofoblasto humano y de rata mediante la t\u00e9cnica de filtraci\u00f3n r\u00e1pida. Estudios de biodistribuci\u00f3n de cisplatino y bamet-r2 en ratas gestantes. resultados:durante la gestaci\u00f3n normal se produce un aumento paulatinos de la colanemia, incrementandose la frecuencia de la hipercolanemia subcl\u00ednica en el tercer trimestre. Durante la cig se produce un aumento significativo de la concentraci\u00f3n de \u00e1cidos biliares en suero y elevaci\u00f3n de las concentraciones s\u00e9ricas de los marcadores bioqu\u00edmicos hep\u00e1ticos que disminuyen con el tratamiento con audc. Se produce una disminuci\u00f3n de la eficacia de los transportadores presentes en las membranas plasm\u00e1ticas apical y basal del trofoblasto. el audc revierte este<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hipercolanemia gestacional. estudio epidemiol\u00f3gico en la regi\u00f3n de salamanca durante 1996-1999 y an\u00e1lisis del efecto sobre la transferencia placentaria de \u00e1cidos biliares en modelos experimentales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hipercolanemia gestacional. estudio epidemiol\u00f3gico en la regi\u00f3n de salamanca durante 1996-1999 y an\u00e1lisis del efecto sobre la transferencia placentaria de \u00e1cidos biliares en modelos experimentales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jes\u00fas Pascual Vallejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gonzalez de buitrago arriero Jos\u00e9 manuel <\/li>\n<li>pilar Sanchez collado (vocal)<\/li>\n<li> Alonso de la torre sara raquel (vocal)<\/li>\n<li> Martin vivaldi Martinez Rafael (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jes\u00fas Pascual Vallejo Introducci\u00f3n:la colestasis intrahep\u00e1tica gestacional(cig) es una enfermedad poco frecuente en nuestro pa\u00eds, aunque [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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