{"id":85876,"date":"2000-12-07T00:00:00","date_gmt":"2000-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-precla%c2%adnico-de-un-protocolo-de-terapia-genica-en-tejido-hematopoyetico\/"},"modified":"2000-12-07T00:00:00","modified_gmt":"2000-12-07T00:00:00","slug":"desarrollo-precla%c2%adnico-de-un-protocolo-de-terapia-genica-en-tejido-hematopoyetico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-precla%c2%adnico-de-un-protocolo-de-terapia-genica-en-tejido-hematopoyetico\/","title":{"rendered":"Desarrollo precl\u00ednico de un protocolo de terapia g\u00e9nica en tejido hematopoy\u00e9tico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Serrano Gomez <\/strong><\/h2>\n<p>La terapia g\u00e9nica humana ofrece perspectivas de tratamiento para diversas enfermedades gen\u00e9ticas hereditarias o adquiridas. Entre las diversas dianas para la inserci\u00f3n de genes terap\u00e9uticos el tejido hematopoy\u00e9tico ha recibido la m\u00e1xima atenci\u00f3n debido a su facilidad de obtenci\u00f3n, su capacidad de injerto en la m\u00e9dula \u00f3sea del receptor y, sobre todo, a su potencialmente ilimitada capacidad de autorenovaci\u00f3n. Con el fin de desarrollar un protocolo de transferencia g\u00e9nica precl\u00ednico se han realizado transplantes de progenitores hematopoy\u00e9ticos humanos, utilizando como modelo el rat\u00f3n nod\/scid. Estos resultados muestran la presencia de c\u00e9lulas capaces de injertar en el rat\u00f3n nod\/scid que ocurren en la fracci\u00f3n mononuclear y en la fracci\u00f3n cd34+ y sugiere la existencia de un tipo celular (src) capaz de producir un injerto con propiedades de renovaci\u00f3n y automantenimiento t\u00edpicos de la c\u00e9lula troncal hematopoy\u00e9tica. El modelo de xenotransplante humano en rat\u00f3n nod\/scid mimetiza los aspectos fundamentales de transplante de progenitores hematopoy\u00e9ticos humanos. Se seleccionaron diversos vectores retrovirales para la tranferencia g\u00e9nica de las c\u00e9lulas hematopoy\u00e9ticas utilizando el marcador superficie de seguridad biol\u00f3gica ahughr+ desarrollado por nosotros la exposici\u00f3n m\u00faltiple a sobrenadantes retrovirales concentrados de este vector produce transferencia g\u00e9nica de la c\u00e9lula que repuebla al animal scid.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo precl\u00ednico de un protocolo de terapia g\u00e9nica en tejido hematopoy\u00e9tico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo precl\u00ednico de un protocolo de terapia g\u00e9nica en tejido hematopoy\u00e9tico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Serrano Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Bernad Miana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis EnJuan es sanchez <\/li>\n<li>Juan  Antonio Bueren roncero (vocal)<\/li>\n<li>Jorge Barquinero maez (vocal)<\/li>\n<li>Rafael Delgado vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Serrano Gomez La terapia g\u00e9nica humana ofrece perspectivas de tratamiento para diversas enfermedades gen\u00e9ticas hereditarias o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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