{"id":85893,"date":"2018-03-10T00:10:25","date_gmt":"2018-03-10T00:10:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-asociados-a-la-accion-de-las-citoquinas-en-el-musculo-esqueletico\/"},"modified":"2018-03-10T00:10:25","modified_gmt":"2018-03-10T00:10:25","slug":"mecanismos-moleculares-asociados-a-la-accion-de-las-citoquinas-en-el-musculo-esqueletico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-moleculares-asociados-a-la-accion-de-las-citoquinas-en-el-musculo-esqueletico\/","title":{"rendered":"Mecanismos moleculares asociados a la accion de las citoquinas en el musculo esqueletico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen Alvarez Palomo <\/strong><\/h2>\n<p>La caquexia cancerosa es un s\u00edndrome responsable de muchos de los fallecimientos de los pacientes con tumor y que entre otras caracteristicas incluye una fuerte p\u00e9rdida de peso, alteraciones metab\u00f3licas y debilidad debida al desgaste de los m\u00fasculos esquel\u00e9ticos. Estudios in vivo han puesto de manifiesto el papel de la citoquinas producidas por el sistema inmunitario en respuesta al tumor, y en especial el factor de necrosis tumoral-a(tnf-a), en la aceleraci\u00f3n de la prote\u00f3lisis muscular.  el primer objetivo de esta tesis fue el de caracterizar la acci\u00f3n directa del tnf-a sobre el metabolismo proteico muscular en cultivos de la linea muscular c2c12. Se encontr\u00f3 que, in vitro, la acci\u00f3n del tnf-a result\u00f3 ser bimodal: a baja dosis de tnf-a fue catab\u00f3lica y a altas dosis, anab\u00f3lica. la caracterizaci\u00f3n de la acci\u00f3n anab\u00f3lica revel\u00f3 que era debido tanto a cambios en la s\u00edntesis como en la degradaci\u00f3n proteica, que posiblemente esta mediada por la inducci\u00f3n dela producci\u00f3n de interleuquinas (il-6) end\u00f3gena y que es dependiente de la sintesis de dna.  tambien se llevaron a cabo estudios con ratas portadoras del hepatoma asc\u00edtico yoshida ah-130 y ratones portadores del carcinoma pulmonar de lewis destinados a buscar estrategias terapeuticas anticaqu\u00e9ticas. Los inhibidores de la sintesis de tnf-a (el inhibidor d ela fosfodiesterasa iv emd 95932 y el doble inhibidor de la sintesis de tnf-a e il-1 fr167653) mostraron ser ineficaces en la reversi\u00f3n de las alteraciones asociadas a la caquexia. sin embargo el tratamiento con il-15, citoquina que ha mostrado propiedades anab\u00f3licas en cultivos de l\u00edneas musculares, mostr\u00f3 una acci\u00f3n protectora del desgaste muscular mediante el bloqueo de la activaci\u00f3n de las prote\u00f3lisis, y en particular del sistema proteol\u00edtico dependiente de ubiquitina, ya que previamente descrito que acompa\u00f1a a la presencia del tumor. La acci\u00f3n de esta citoquina sobre el musculo esqueletico es posibleme<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares asociados a la accion de las citoquinas en el musculo esqueletico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares asociados a la accion de las citoquinas en el musculo esqueletico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen Alvarez Palomo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier L\u00f3pez Soriano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduard Escrich escriche <\/li>\n<li>Jos\u00e9 Antonio Fernandez lopez (vocal)<\/li>\n<li>josep Roca torrent (vocal)<\/li>\n<li>paola Costelli (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen Alvarez Palomo La caquexia cancerosa es un s\u00edndrome responsable de muchos de los fallecimientos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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